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Items: 1 to 20 of 161

1.

Discovery of macrocyclic inhibitors of Apurinic/apyrimidinic endonuclease 1.

Trilles R, Beglov D, Chen Q, He H, Wireman R, Reed A, Chennamadhavuni S, Panek JS, Brown LE, Vajda S, Porco JA, Kelley MR, Georgiadis MM.

J Med Chem. 2019 Jan 17. doi: 10.1021/acs.jmedchem.8b01529. [Epub ahead of print]

PMID:
30653918
2.

Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.

Kearney SE, Zahoránszky-Kőhalmi G, Brimacombe KR, Henderson MJ, Lynch C, Zhao T, Wan KK, Itkin Z, Dillon C, Shen M, Cheff DM, Lee TD, Bougie D, Cheng K, Coussens NP, Dorjsuren D, Eastman RT, Huang R, Iannotti MJ, Karavadhi S, Klumpp-Thomas C, Roth JS, Sakamuru S, Sun W, Titus SA, Yasgar A, Zhang YQ, Zhao J, Andrade RB, Brown MK, Burns NZ, Cha JK, Mevers EE, Clardy J, Clement JA, Crooks PA, Cuny GD, Ganor J, Moreno J, Morrill LA, Picazo E, Susick RB, Garg NK, Goess BC, Grossman RB, Hughes CC, Johnston JN, Joullie MM, Kinghorn AD, Kingston DGI, Krische MJ, Kwon O, Maimone TJ, Majumdar S, Maloney KN, Mohamed E, Murphy BT, Nagorny P, Olson DE, Overman LE, Brown LE, Snyder JK, Porco JA Jr, Rivas F, Ross SA, Sarpong R, Sharma I, Shaw JT, Xu Z, Shen B, Shi W, Stephenson CRJ, Verano AL, Tan DS, Tang Y, Taylor RE, Thomson RJ, Vosburg DA, Wu J, Wuest WM, Zakarian A, Zhang Y, Ren T, Zuo Z, Inglese J, Michael S, Simeonov A, Zheng W, Shinn P, Jadhav A, Boxer MB, Hall MD, Xia M, Guha R, Rohde JM.

ACS Cent Sci. 2018 Dec 26;4(12):1727-1741. doi: 10.1021/acscentsci.8b00747. Epub 2018 Dec 5.

3.

Chemical Synthesis Enables Structural Reengineering of Aglaroxin C Leading to Inhibition Bias for HCV Infection.

Zhang W, Liu S, Maiga RI, Pelletier J, Brown LE, Wang TT, Porco JA.

J Am Chem Soc. 2018 Dec 27. doi: 10.1021/jacs.8b11477. [Epub ahead of print]

PMID:
30590924
4.

Asymmetric Synthesis of Griffipavixanthone Employing a Chiral Phosphoric Acid-Catalyzed Cycloaddition.

Smith MJ, Reichl KD, Escobar RA, Heavey T, Coker DF, Schaus SE, Porco JA.

J Am Chem Soc. 2018 Dec 19. doi: 10.1021/jacs.8b12520. [Epub ahead of print]

PMID:
30566336
5.

Sensitization of renal carcinoma cells to TRAIL-induced apoptosis by rocaglamide and analogs.

Nalli AD, Brown LE, Thomas CL, Sayers TJ, Porco JA Jr, Henrich CJ.

Sci Rep. 2018 Nov 30;8(1):17519. doi: 10.1038/s41598-018-35908-0.

6.

Diastereodivergent synthesis of chiral tetrahydropyrrolodiazepinediones via a one-pot intramolecular aza-Michael/lactamization sequence.

Chennamadhavuni S, Panek JS, Porco JA, Brown LE.

J Org Chem. 2018 Nov 20. doi: 10.1021/acs.joc.8b02724. [Epub ahead of print]

PMID:
30458107
7.

Eucalyptusdimers A-C, Dimeric Phloroglucinol-Phellandrene Meroterpenoids from Eucalyptus robusta.

Qin XJ, Feng MY, Liu H, Ni W, Rauwolf T, Porco JA Jr, Yan H, He L, Liu HY.

Org Lett. 2018 Aug 17;20(16):5066-5070. doi: 10.1021/acs.orglett.8b02259. Epub 2018 Aug 8.

PMID:
30088934
8.

High-throughput Screening in Larval Zebrafish Identifies Novel Potent Sedative-hypnotics.

Yang X, Jounaidi Y, Dai JB, Marte-Oquendo F, Halpin ES, Brown LE, Trilles R, Xu W, Daigle R, Yu B, Schaus SE, Porco JA Jr, Forman SA.

Anesthesiology. 2018 Sep;129(3):459-476. doi: 10.1097/ALN.0000000000002281.

PMID:
29894316
9.

Asymmetric Synthesis of Gonytolide A: Strategic Use of an Aryl Halide Blocking Group for Oxidative Coupling.

Wu X, Iwata T, Scharf A, Qin T, Reichl KD, Porco JA Jr.

J Am Chem Soc. 2018 May 9;140(18):5969-5975. doi: 10.1021/jacs.8b02535. Epub 2018 Apr 25.

PMID:
29658717
10.

Rocaglates as dual-targeting agents for experimental cerebral malaria.

Langlais D, Cencic R, Moradin N, Kennedy JM, Ayi K, Brown LE, Crandall I, Tarry MJ, Schmeing M, Kain KC, Porco JA Jr, Pelletier J, Gros P.

Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):E2366-E2375. doi: 10.1073/pnas.1713000115. Epub 2018 Feb 20.

11.

Total Synthesis of Aurofusarin: Studies on the Atropisomeric Stability of Bis-Naphthoquinones.

Qi C, Wang W, Reichl KD, McNeely J, Porco JA Jr.

Angew Chem Int Ed Engl. 2018 Feb 19;57(8):2101-2104. doi: 10.1002/anie.201711535. Epub 2018 Jan 29.

PMID:
29318760
12.

Total Syntheses of the Isomeric Aglain Natural Products Foveoglin A and Perviridisin B: Selective Excited-State Intramolecular Proton-Transfer Photocycloaddition.

Wang W, Clay A, Krishnan R, Lajkiewicz NJ, Brown LE, Sivaguru J, Porco JA Jr.

Angew Chem Int Ed Engl. 2017 Nov 13;56(46):14479-14482. doi: 10.1002/anie.201707539. Epub 2017 Oct 13.

13.

Biomimetic Total Synthesis of (±)-Griffipavixanthone via a Cationic Cycloaddition-Cyclization Cascade.

Reichl KD, Smith MJ, Song MK, Johnson RP, Porco JA Jr.

J Am Chem Soc. 2017 Oct 11;139(40):14053-14056. doi: 10.1021/jacs.7b09265. Epub 2017 Oct 2.

14.

A photochemical flow reactor for large scale syntheses of aglain and rocaglate natural product analogues.

Yueh H, Gao Q, Porco JA Jr, Beeler AB.

Bioorg Med Chem. 2017 Dec 1;25(23):6197-6202. doi: 10.1016/j.bmc.2017.06.010. Epub 2017 Jun 11.

15.

Inhibiting the oncogenic translation program is an effective therapeutic strategy in multiple myeloma.

Manier S, Huynh D, Shen YJ, Zhou J, Yusufzai T, Salem KZ, Ebright RY, Shi J, Park J, Glavey SV, Devine WG, Liu CJ, Leleu X, Quesnel B, Roche-Lestienne C, Snyder JK, Brown LE, Gray N, Bradner J, Whitesell L, Porco JA Jr, Ghobrial IM.

Sci Transl Med. 2017 May 10;9(389). pii: eaal2668. doi: 10.1126/scitranslmed.aal2668.

16.

Asymmetric Dearomatization/Cyclization Enables Access to Polycyclic Chemotypes.

Hayashi M, Brown LE, Porco JA Jr.

European J Org Chem. 2016 Oct;2016(28):4800-4804. doi: 10.1002/ejoc.201601003.

17.

Development of a Potent and Selective HDAC8 Inhibitor.

Ingham OJ, Paranal RM, Smith WB, Escobar RA, Yueh H, Snyder T, Porco JA Jr, Bradner JE, Beeler AB.

ACS Med Chem Lett. 2016 Sep 1;7(10):929-932. eCollection 2016 Oct 13.

19.

Synthesis of Aza-Rocaglates via ESIPT-Mediated (3+2) Photocycloaddition.

Wang W, Cencic R, Whitesell L, Pelletier J, Porco JA Jr.

Chemistry. 2016 Aug 16;22(34):12006-10. doi: 10.1002/chem.201602953. Epub 2016 Jul 15.

20.

CRISPR-Mediated Drug-Target Validation Reveals Selective Pharmacological Inhibition of the RNA Helicase, eIF4A.

Chu J, Galicia-Vázquez G, Cencic R, Mills JR, Katigbak A, Porco JA Jr, Pelletier J.

Cell Rep. 2016 Jun 14;15(11):2340-7. doi: 10.1016/j.celrep.2016.05.005. Epub 2016 May 26.

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