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Items: 1 to 20 of 136

1.

Physical exercise prevents alterations in purinergic system and oxidative status in lipopolysaccharide-induced sepsis in rats.

Miron VV, Bottari NB, Assmann CE, Stefanello N, da Costa P, Pelinson LP, Reichert KP, da Silva AD, Lopes TF, da Cruz IBM, Sévigny J, Morsch VM, Schetinger MRC, Cardoso AM.

J Cell Biochem. 2018 Sep 19. doi: 10.1002/jcb.27590. [Epub ahead of print]

PMID:
30230598
2.

Ectonucleotidase inhibitory and redox activity of imidazole-based organic salts and ionic liquids.

Macaev F, Boldescu V, Sucman N, Hassan S, Iqbal J, Neamțu M, Lecka J, Sevigny J, Prodius D.

ChemMedChem. 2018 Sep 7. doi: 10.1002/cmdc.201800520. [Epub ahead of print]

PMID:
30192439
3.

CD73 Downregulation Decreases In Vitro and In Vivo Glioblastoma Growth.

Azambuja JH, Gelsleichter NE, Beckenkamp LR, Iser IC, Fernandes MC, Figueiró F, Battastini AMO, Scholl JN, de Oliveira FH, Spanevello RM, Sévigny J, Wink MR, Stefani MA, Teixeira HF, Braganhol E.

Mol Neurobiol. 2018 Aug 16. doi: 10.1007/s12035-018-1240-4. [Epub ahead of print]

PMID:
30117104
4.

Exploration of carboxy pyrazole derivatives: Synthesis, alkaline phosphatase, nucleotide pyrophosphatase/phosphodiesterase and nucleoside triphosphate diphosphohydrolase inhibition studies with potential anticancer profile.

Channar PA, Afzal S, Ejaz SA, Saeed A, Larik FA, Mahesar PA, Lecka J, Sévigny J, Erben MF, Iqbal J.

Eur J Med Chem. 2018 Aug 5;156:461-478. doi: 10.1016/j.ejmech.2018.07.002. Epub 2018 Jul 7.

PMID:
30015078
5.

Highly Selective and Potent Ectonucleotide Pyrophosphatase-1 (NPP1) Inhibitors Based on Uridine 5'-Pα,α-Dithiophosphate Analogues.

Zelikman V, Pelletier J, Simhaev L, Sela A, Gendron FP, Arguin G, Senderowitz H, Sévigny J, Fischer B.

J Med Chem. 2018 May 10;61(9):3939-3951. doi: 10.1021/acs.jmedchem.7b01906. Epub 2018 May 2.

PMID:
29681152
6.

P2Y6 Receptors Regulate CXCL10 Expression and Secretion in Mouse Intestinal Epithelial Cells.

Salem M, Tremblay A, Pelletier J, Robaye B, Sévigny J.

Front Pharmacol. 2018 Feb 28;9:149. doi: 10.3389/fphar.2018.00149. eCollection 2018.

7.

Tricyclic coumarin sulphonate derivatives with alkaline phosphatase inhibitory effects: in vitro and docking studies.

Iqbal J, El-Gamal MI, Ejaz SA, Lecka J, Sévigny J, Oh CH.

J Enzyme Inhib Med Chem. 2018 Dec;33(1):479-484. doi: 10.1080/14756366.2018.1428193.

8.

Distinctive inhibition of alkaline phosphatase isozymes by thiazol-2-ylidene-benzamide derivatives: Functional insights into their anticancer role.

Ejaz SA, Saeed A, Shah SJA, Hameed A, Lecka J, Sévigny J, Iqbal J.

J Cell Biochem. 2018 Aug;119(8):6501-6513. doi: 10.1002/jcb.26692. Epub 2018 Apr 18.

PMID:
29363794
9.

Ecto-5'-nucleotidase/CD73 contributes to the radiosensitivity of T24 human bladder cancer cell line.

Dietrich F, Figueiró F, Filippi-Chiela EC, Cappellari AR, Rockenbach L, Tremblay A, de Paula PB, Roesler R, Filho AB, Sévigny J, Morrone FB, Battastini AMO.

J Cancer Res Clin Oncol. 2018 Mar;144(3):469-482. doi: 10.1007/s00432-017-2567-3. Epub 2018 Jan 5.

PMID:
29305710
10.

A domino reaction of 3-chlorochromones with aminoheterocycles. Synthesis of pyrazolopyridines and benzofuropyridines and their optical and ecto-5'-nucleotidase inhibitory effects.

Miliutina M, Janke J, Hassan S, Zaib S, Iqbal J, Lecka J, Sévigny J, Villinger A, Friedrich A, Lochbrunner S, Langer P.

Org Biomol Chem. 2018 Jan 31;16(5):717-732. doi: 10.1039/c7ob02729j.

PMID:
29303198
11.

Characterization of ecto-nucleotidases in human oviducts with an improved approach simultaneously identifying protein expression and in situ enzyme activity.

Villamonte ML, Torrejón-Escribano B, Rodríguez-Martínez A, Trapero C, Vidal A, Gómez de Aranda I, Sévigny J, Matías-Guiu X, Martín-Satué M.

Histochem Cell Biol. 2018 Mar;149(3):269-276. doi: 10.1007/s00418-017-1627-8. Epub 2017 Dec 22.

PMID:
29273916
12.

2-Substituted 7-trifluoromethyl-thiadiazolopyrimidones as alkaline phosphatase inhibitors. Synthesis, structure activity relationship and molecular docking study.

Jafari B, Ospanov M, Ejaz SA, Yelibayeva N, Khan SU, Amjad ST, Safarov S, Abilov ZA, Turmukhanova MZ, Kalugin SN, Ehlers P, Lecka J, Sévigny J, Iqbal J, Langer P.

Eur J Med Chem. 2018 Jan 20;144:116-127. doi: 10.1016/j.ejmech.2017.11.068. Epub 2017 Dec 6.

PMID:
29268128
13.

Loss of vascular expression of nucleoside triphosphate diphosphohydrolase-1/CD39 in hypertension.

Roy C, Tabiasco J, Caillon A, Delneste Y, Merot J, Favre J, Guihot AL, Martin L, Nascimento DC, Ryffel B, Robson SC, Sévigny J, Henrion D, Kauffenstein G.

Purinergic Signal. 2018 Mar;14(1):73-82. doi: 10.1007/s11302-017-9597-9. Epub 2017 Dec 13.

14.

4-Aminopyridine based amide derivatives as dual inhibitors of tissue non-specific alkaline phosphatase and ecto-5'-nucleotidase with potential anticancer activity.

Hassan S, Ejaz SA, Saeed A, Shehzad M, Ullah Khan S, Lecka J, Sévigny J, Shabir G, Iqbal J.

Bioorg Chem. 2018 Feb;76:237-248. doi: 10.1016/j.bioorg.2017.11.013. Epub 2017 Nov 21.

PMID:
29197225
15.

Down-regulation of NTPDase2 and ADP-sensitive P2 Purinoceptors Correlate with Severity of Symptoms during Experimental Autoimmune Encephalomyelitis.

Jakovljevic M, Lavrnja I, Bozic I, Savic D, Bjelobaba I, Pekovic S, Sévigny J, Nedeljkovic N, Laketa D.

Front Cell Neurosci. 2017 Oct 30;11:333. doi: 10.3389/fncel.2017.00333. eCollection 2017.

16.

Distinct roles of ecto-nucleoside triphosphate diphosphohydrolase-2 (NTPDase2) in liver regeneration and fibrosis.

Feldbrügge L, Jiang ZG, Csizmadia E, Mitsuhashi S, Tran S, Yee EU, Rothweiler S, Vaid KA, Sévigny J, Schmelzle M, Popov YV, Robson SC.

Purinergic Signal. 2018 Mar;14(1):37-46. doi: 10.1007/s11302-017-9590-3. Epub 2017 Nov 13.

17.

Chemoselective synthesis and biological evaluation of arylated 2-(Trifluoromethyl) quinolines as nucleotide pyrophosphatase (NPPs) inhibitors.

Kuhrt D, Ejaz SA, Afzal S, Khan SU, Lecka J, Sévigny J, Ehlers P, Spannenberg A, Iqbal J, Langer P.

Eur J Med Chem. 2017 Sep 29;138:816-829. doi: 10.1016/j.ejmech.2017.07.017. Epub 2017 Jul 13.

PMID:
28735213
18.

Expression of Ecto-nucleoside Triphosphate Diphosphohydrolases-2 and -3 in the Enteric Nervous System Affects Inflammation in Experimental Colitis and Crohn's Disease.

Feldbrügge L, Moss AC, Yee EU, Csizmadia E, Mitsuhashi S, Longhi MS, Sandhu B, Stephan H, Wu Y, Cheifetz AS, Müller CE, Sévigny J, Robson SC, Jiang ZG.

J Crohns Colitis. 2017 Sep 1;11(9):1113-1123. doi: 10.1093/ecco-jcc/jjx058.

19.

Generation and characterization of polyclonal and monoclonal antibodies to human NTPDase2 including a blocking antibody.

Pelletier J, Agonsanou H, Delvalle N, Fausther M, Salem M, Gulbransen B, Sévigny J.

Purinergic Signal. 2017 Sep;13(3):293-304. doi: 10.1007/s11302-017-9561-8. Epub 2017 Apr 13.

20.

Generation and Characterization of Specific Antibodies to the Murine and Human Ectonucleotidase NTPDase8.

Pelletier J, Salem M, Lecka J, Fausther M, Bigonnesse F, Sévigny J.

Front Pharmacol. 2017 Mar 8;8:115. doi: 10.3389/fphar.2017.00115. eCollection 2017.

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