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Items: 1 to 20 of 80

1.

Apicomplexan F-actin is required for efficient nuclear entry during host cell invasion.

Del Rosario M, Periz J, Pavlou G, Lyth O, Latorre-Barragan F, Das S, Pall GS, Stortz JF, Lemgruber L, Whitelaw JA, Baum J, Tardieux I, Meissner M.

EMBO Rep. 2019 Oct 4:e48896. doi: 10.15252/embr.201948896. [Epub ahead of print]

2.

Quantitative and rapid Plasmodium falciparum malaria diagnosis and artemisinin-resistance detection using a CMOS Lab-on-Chip platform.

Malpartida-Cardenas K, Miscourides N, Rodriguez-Manzano J, Yu LS, Moser N, Baum J, Georgiou P.

Biosens Bioelectron. 2019 Dec 1;145:111678. doi: 10.1016/j.bios.2019.111678. Epub 2019 Sep 7.

PMID:
31541787
3.

Structure-Activity Relationship Studies of a Novel Class of Transmission Blocking Antimalarials Targeting Male Gametes.

Rueda-Zubiaurre A, Yahiya S, Fischer OJ, Hu X, Saunders CN, Sharma S, Straschil U, Shen J, Tate EW, Delves MJ, Baum J, Barnard A, Fuchter MJ.

J Med Chem. 2019 Sep 20. doi: 10.1021/acs.jmedchem.9b00898. [Epub ahead of print]

PMID:
31490680
4.

Genetic manipulation of cell line derived reticulocytes enables dissection of host malaria invasion requirements.

Satchwell TJ, Wright KE, Haydn-Smith KL, Sánchez-Román Terán F, Moura PL, Hawksworth J, Frayne J, Toye AM, Baum J.

Nat Commun. 2019 Aug 23;10(1):3806. doi: 10.1038/s41467-019-11790-w.

5.

Plasmodium myosin A drives parasite invasion by an atypical force generating mechanism.

Robert-Paganin J, Robblee JP, Auguin D, Blake TCA, Bookwalter CS, Krementsova EB, Moussaoui D, Previs MJ, Jousset G, Baum J, Trybus KM, Houdusse A.

Nat Commun. 2019 Jul 23;10(1):3286. doi: 10.1038/s41467-019-11120-0.

6.

Design of a basigin-mimicking inhibitor targeting the malaria invasion protein RH5.

Warszawski S, Dekel E, Campeotto I, Marshall JM, Wright KE, Lyth O, Knop O, Regev-Rudzki N, Higgins MK, Draper SJ, Baum J, Fleishman SJ.

Proteins. 2019 Jul 20. doi: 10.1002/prot.25786. [Epub ahead of print]

PMID:
31325330
7.

Divergent roles for the RH5 complex components, CyRPA and RIPR in human-infective malaria parasites.

Knuepfer E, Wright KE, Kumar Prajapati S, Rawlinson TA, Mohring F, Koch M, Lyth OR, Howell SA, Villasis E, Snijders AP, Moon RW, Draper SJ, Rosanas-Urgell A, Higgins MK, Baum J, Holder AA.

PLoS Pathog. 2019 Jun 11;15(6):e1007809. doi: 10.1371/journal.ppat.1007809. eCollection 2019 Jun.

8.

Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis.

Baragaña B, Forte B, Choi R, Nakazawa Hewitt S, Bueren-Calabuig JA, Pisco JP, Peet C, Dranow DM, Robinson DA, Jansen C, Norcross NR, Vinayak S, Anderson M, Brooks CF, Cooper CA, Damerow S, Delves M, Dowers K, Duffy J, Edwards TE, Hallyburton I, Horst BG, Hulverson MA, Ferguson L, Jiménez-Díaz MB, Jumani RS, Lorimer DD, Love MS, Maher S, Matthews H, McNamara CW, Miller P, O'Neill S, Ojo KK, Osuna-Cabello M, Pinto E, Post J, Riley J, Rottmann M, Sanz LM, Scullion P, Sharma A, Shepherd SM, Shishikura Y, Simeons FRC, Stebbins EE, Stojanovski L, Straschil U, Tamaki FK, Tamjar J, Torrie LS, Vantaux A, Witkowski B, Wittlin S, Yogavel M, Zuccotto F, Angulo-Barturen I, Sinden R, Baum J, Gamo FJ, Mäser P, Kyle DE, Winzeler EA, Myler PJ, Wyatt PG, Floyd D, Matthews D, Sharma A, Striepen B, Huston CD, Gray DW, Fairlamb AH, Pisliakov AV, Walpole C, Read KD, Van Voorhis WC, Gilbert IH.

Proc Natl Acad Sci U S A. 2019 Apr 2;116(14):7015-7020. doi: 10.1073/pnas.1814685116. Epub 2019 Mar 20.

9.

The antimalarial screening landscape-looking beyond the asexual blood stage.

Yahiya S, Rueda-Zubiaurre A, Delves MJ, Fuchter MJ, Baum J.

Curr Opin Chem Biol. 2019 Jun;50:1-9. doi: 10.1016/j.cbpa.2019.01.029. Epub 2019 Mar 12. Review.

10.

Epistasis studies reveal redundancy among calcium-dependent protein kinases in motility and invasion of malaria parasites.

Fang H, Gomes AR, Klages N, Pino P, Maco B, Walker EM, Zenonos ZA, Angrisano F, Baum J, Doerig C, Baker DA, Billker O, Brochet M.

Nat Commun. 2018 Oct 12;9(1):4248. doi: 10.1038/s41467-018-06733-w.

11.

A high throughput screen for next-generation leads targeting malaria parasite transmission.

Delves MJ, Miguel-Blanco C, Matthews H, Molina I, Ruecker A, Yahiya S, Straschil U, Abraham M, León ML, Fischer OJ, Rueda-Zubiaurre A, Brandt JR, Cortés Á, Barnard A, Fuchter MJ, Calderón F, Winzeler EA, Sinden RE, Herreros E, Gamo FJ, Baum J.

Nat Commun. 2018 Sep 18;9(1):3805. doi: 10.1038/s41467-018-05777-2.

12.

Allele-Specific Isothermal Amplification Method Using Unmodified Self-Stabilizing Competitive Primers.

Malpartida-Cardenas K, Rodriguez-Manzano J, Yu LS, Delves MJ, Nguon C, Chotivanich K, Baum J, Georgiou P.

Anal Chem. 2018 Oct 16;90(20):11972-11980. doi: 10.1021/acs.analchem.8b02416. Epub 2018 Oct 2.

13.

An inexpensive open source 3D-printed membrane feeder for human malaria transmission studies.

Witmer K, Sherrard-Smith E, Straschil U, Tunnicliff M, Baum J, Delves M.

Malar J. 2018 Aug 3;17(1):282. doi: 10.1186/s12936-018-2436-9.

14.

Cellular dissection of malaria parasite invasion of human erythrocytes using viable Plasmodium knowlesi merozoites.

Lyth O, Vizcay-Barrena G, Wright KE, Haase S, Mohring F, Najer A, Henshall IG, Ashdown GW, Bannister LH, Drew DR, Beeson JG, Fleck RA, Moon RW, Wilson DW, Baum J.

Sci Rep. 2018 Jul 5;8(1):10165. doi: 10.1038/s41598-018-28457-z.

15.

Development of a Photo-Cross-Linkable Diaminoquinazoline Inhibitor for Target Identification in Plasmodium falciparum.

Lubin AS, Rueda-Zubiaurre A, Matthews H, Baumann H, Fisher FR, Morales-Sanfrutos J, Hadavizadeh KS, Nardella F, Tate EW, Baum J, Scherf A, Fuchter MJ.

ACS Infect Dis. 2018 Apr 13;4(4):523-530. doi: 10.1021/acsinfecdis.7b00228. Epub 2018 Feb 5.

16.

Reconstitution of the core of the malaria parasite glideosome with recombinant Plasmodium class XIV myosin A and Plasmodium actin.

Bookwalter CS, Tay CL, McCrorie R, Previs MJ, Lu H, Krementsova EB, Fagnant PM, Baum J, Trybus KM.

J Biol Chem. 2017 Nov 24;292(47):19290-19303. doi: 10.1074/jbc.M117.813972. Epub 2017 Oct 4.

17.

Multiple essential functions of Plasmodium falciparum actin-1 during malaria blood-stage development.

Das S, Lemgruber L, Tay CL, Baum J, Meissner M.

BMC Biol. 2017 Aug 15;15(1):70. doi: 10.1186/s12915-017-0406-2.

18.

Hundreds of dual-stage antimalarial molecules discovered by a functional gametocyte screen.

Miguel-Blanco C, Molina I, Bardera AI, Díaz B, de Las Heras L, Lozano S, González C, Rodrigues J, Delves MJ, Ruecker A, Colmenarejo G, Viera S, Martínez-Martínez MS, Fernández E, Baum J, Sinden RE, Herreros E.

Nat Commun. 2017 May 17;8:15160. doi: 10.1038/ncomms15160.

19.

Plasmodium falciparum erythrocyte-binding antigen 175 triggers a biophysical change in the red blood cell that facilitates invasion.

Koch M, Wright KE, Otto O, Herbig M, Salinas ND, Tolia NH, Satchwell TJ, Guck J, Brooks NJ, Baum J.

Proc Natl Acad Sci U S A. 2017 Apr 18;114(16):4225-4230. doi: 10.1073/pnas.1620843114. Epub 2017 Apr 3.

20.

Mefloquine targets the Plasmodium falciparum 80S ribosome to inhibit protein synthesis.

Wong W, Bai XC, Sleebs BE, Triglia T, Brown A, Thompson JK, Jackson KE, Hanssen E, Marapana DS, Fernandez IS, Ralph SA, Cowman AF, Scheres SHW, Baum J.

Nat Microbiol. 2017 Mar 13;2:17031. doi: 10.1038/nmicrobiol.2017.31.

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