Format

Send to

Choose Destination
J Leukoc Biol. 2007 Jan;81(1):154-60. Epub 2006 Sep 13.

Lipids in dendritic cell biology: messengers, effectors, and antigens.

Author information

1
Department of Urology, Innsbruck Medical University, and Kompetenzzentrum Medizin Tirol, Austria. martin.thurnher@uibk.ac.at

Abstract

Dendritic cells (DC) are the most professional APC, which induce and coordinate immune responses. The principal task of DC is T cell activation, although DC also interact with and regulate other cell types. The present review serves to illustrate the increasing evidence that lipids play an important role in DC biology. In addition to being fuel stores and structural components of cellular membranes such as in other cell types, lipids act as second messengers and as effectors throughout all steps of DC differentiation and regulate important DC functions. The recent finding that DC synthesize lipid antigens in response to bacterial stimulation and induce antibacterial, CD1-restricted T cells through antigenic mimicry further emphasizes the important role of lipids and DC at the blurring boundaries of innate and adaptive immunity.

PMID:
16971465
DOI:
10.1189/jlb.0706438
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center