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See 1 citation in J Clin Pathol 2007:

J Clin Pathol. 2007 Aug;60(8):927-30. Epub 2006 Dec 8.

Urine cytology screening for polyoma virus infection following renal transplantation: the Oxford experience.

Author information

1
Department of Pathology, National University of Singapore, National University Hospital, Singapore.

Abstract

OBJECTIVE:

To review the first year of a monthly urine cytology screening service, introduced to identify renal transplant patients at risk of polyoma virus nephropathy (PVN), at an early, potentially treatable, stage.

METHODS AND RESULTS:

Monthly urine samples (n = 392) were received from 97/108 transplant recipients in 2005. Of 56 patients with follow-up >6 months, 20% and 9% had significant (>10 decoy cells/cytospin) and non-significant positive cytology, respectively. The first positive urine samples occurred most commonly in the second and third month post-transplantation and patients with significantly positive samples had higher 3-month and 6-month serum creatinine levels than patients with negative urine cytology (p<0.01). Four patients with positive urine cytology had a subsequent positive plasma BK virus PCR; 3/97 patients had biopsy-proven PVN, all in the third month, 1-6 weeks after first positive urine samples.

CONCLUSIONS:

Significant PV viruria is common following renal transplantation with onset usually within the first 3 months. Viruria is associated with worse graft function at 3 and 6 months. The time between urine positivity and clinical PVN is short. More frequent early urine screening would be required to achieve clinical benefit.

PMID:
17158638
PMCID:
PMC1994480
DOI:
10.1136/jcp.2006.042507
[Indexed for MEDLINE]
Free PMC Article

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