Format

Send to

Choose Destination

See 1 citation found using an alternative search:

J Clin Invest. 2009 May;119(5):1066-73. doi: 10.1172/JCI38010. Epub 2009 May 1.

The role of B lymphocyte stimulator (BLyS) in systemic lupus erythematosus.

Author information

1
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, 19104-6082, USA. cancro@mail.med.upenn.edu

Abstract

SLE, a chronic, multisystem autoimmune disorder with a broad range of symptoms, involves defective B cell selection and elimination of self-reactive B cells. B lymphocyte stimulator (BLyS), a soluble ligand of the TNF cytokine family, is a prominent factor in B cell differentiation, homeostasis, and selection. BLyS levels affect survival signals and selective apoptosis of autoantibody-producing B cells. High levels of BLyS may relax B cell selection and contribute to autoantibody production, exacerbating the SLE disease state. This review discusses the mechanism of BLyS action on B cells, its role in SLE, and specific targeting of BLyS in the treatment of SLE.

PMID:
19411764
PMCID:
PMC2673851
DOI:
10.1172/JCI38010
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for American Society for Clinical Investigation Icon for PubMed Central
Loading ...
Support Center