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134 results

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Page 1
Myelodysplastic Syndromes with Isolated del(5q): Value of Molecular Alterations for Diagnostic and Prognostic Assessment.
Acha P, Mallo M, Solé F. Acha P, et al. Cancers (Basel). 2022 Nov 10;14(22):5531. doi: 10.3390/cancers14225531. Cancers (Basel). 2022. PMID: 36428627 Free PMC article. Review.
Although nearly half of newly diagnosed patients present a cytogenetic alteration, and almost 90% of them harbor at least one somatic mutation, MDS with isolated del(5q) constitutes the only subtype clearly defined by a cytogenetic alteration. ...The aim of t …
Although nearly half of newly diagnosed patients present a cytogenetic alteration, and almost 90% of them harbor at least one somatic mutati …
Diagnosis and classification of myelodysplastic syndromes.
Hasserjian RP, Germing U, Malcovati L. Hasserjian RP, et al. Blood. 2023 Dec 28;142(26):2247-2257. doi: 10.1182/blood.2023020078. Blood. 2023. PMID: 37774372
The current MDS classification schemes incorporate morphologic features (bone marrow and blood blast percentage, degree of dysplasia, ring sideroblasts, bone marrow fibrosis, and bone marrow hypocellularity) and also recognize 3 entities defined by genetics: isolated de …
The current MDS classification schemes incorporate morphologic features (bone marrow and blood blast percentage, degree of dysplasia, ring s …
Isolated del(5q) in Patients Following Therapies for Various Malignancies May Not All Be Clinically Significant.
Tang G, Goswami RS, Liang CS, Bueso-Ramos CE, Hu S, DiNardo C, Medeiros LJ. Tang G, et al. Am J Clin Pathol. 2015 Jul;144(1):78-86. doi: 10.1309/AJCPBADO22WXOFHJ. Am J Clin Pathol. 2015. PMID: 26071464
METHODS: We identified 25 patients who developed isolated del(5q) following cytotoxic therapy (n = 21) or tyrosine kinase inhibitor (TKI; n = 4) therapy. ...By contrast, 12 of 13 patients with a large del(5q) clone developed t-MN, and del …
METHODS: We identified 25 patients who developed isolated del(5q) following cytotoxic therapy (n = 21) or tyrosine kina …
Myelodysplastic disorders carrying both isolated del(5q) and JAK2(V617F) mutation: concise review, with focus on lenalidomide therapy.
Musto P, Simeon V, Guariglia R, Bianchino G, Grieco V, Nozza F, La Rocca F, Marziano G, Lalinga AV, Fabiani E, Voso MT, Scaravaglio P, Mecucci C, D'Arena G. Musto P, et al. Onco Targets Ther. 2014 Jun 13;7:1043-50. doi: 10.2147/OTT.S59628. eCollection 2014. Onco Targets Ther. 2014. PMID: 24966686 Free PMC article. Review.
The concomitant presence of del(5q) and JAK2(V617F) mutation is an infrequent event which occurs in rare patients with peculiar cytogenetic, molecular, morphological and clinical features, resembling those of both myelodysplastic syndromes and myeloproliferative neo …
The concomitant presence of del(5q) and JAK2(V617F) mutation is an infrequent event which occurs in rare patients with peculia …
Isolated del(5q) in myeloid malignancies: clinicopathologic and molecular features in 143 consecutive patients.
Patnaik MM, Lasho TL, Finke CM, Knudson RA, Ketterling RP, Chen D, Hoyer JD, Hanson CA, Tefferi A. Patnaik MM, et al. Am J Hematol. 2011 May;86(5):393-8. doi: 10.1002/ajh.21984. Am J Hematol. 2011. PMID: 21523797 Free article.
World Health Organization (WHO) criteria were used to identify 143 consecutive patients (median age 73 years; 90 females) with myeloid neoplasms and isolated del(5q) seen between 1989 and 2009. We have previously reported on 88 (61%) of these patients who met …
World Health Organization (WHO) criteria were used to identify 143 consecutive patients (median age 73 years; 90 females) with myeloid neopl …
SF3B1-mutant MDS as a distinct disease subtype: a proposal from the International Working Group for the Prognosis of MDS.
Malcovati L, Stevenson K, Papaemmanuil E, Neuberg D, Bejar R, Boultwood J, Bowen DT, Campbell PJ, Ebert BL, Fenaux P, Haferlach T, Heuser M, Jansen JH, Komrokji RS, Maciejewski JP, Walter MJ, Fontenay M, Garcia-Manero G, Graubert TA, Karsan A, Meggendorfer M, Pellagatti A, Sallman DA, Savona MR, Sekeres MA, Steensma DP, Tauro S, Thol F, Vyas P, Van de Loosdrecht AA, Haase D, Tüchler H, Greenberg PL, Ogawa S, Hellstrom-Lindberg E, Cazzola M. Malcovati L, et al. Blood. 2020 Jul 9;136(2):157-170. doi: 10.1182/blood.2020004850. Blood. 2020. PMID: 32347921 Free PMC article. Review.
The 2016 revision of the World Health Organization classification of tumors of hematopoietic and lymphoid tissues is characterized by a closer integration of morphology and molecular genetics. Notwithstanding, the myelodysplastic syndrome (MDS) with isolated del( …
The 2016 revision of the World Health Organization classification of tumors of hematopoietic and lymphoid tissues is characterized by a clos …
Myelodysplastic syndromes del(5q): Pathogenesis and its therapeutic implications.
Bruzzese A, Martino EA, Mendicino F, Lucia E, Olivito V, Capodanno I, Neri A, Morabito F, Vigna E, Gentile M. Bruzzese A, et al. Eur J Haematol. 2024 Jan 31. doi: 10.1111/ejh.14181. Online ahead of print. Eur J Haematol. 2024. PMID: 38294126 Review.
Nearly half of MDS patients carry cytogenetic alterations, with del(5q) being the most prevalent. Since its first description, del(5q) was consistently correlated with a typical clinical phenotype marked by anemia, thrombocytosis, and a low risk of evo …
Nearly half of MDS patients carry cytogenetic alterations, with del(5q) being the most prevalent. Since its first description, …
CSNK1A1 mutations and isolated del(5q) abnormality in myelodysplastic syndrome: a retrospective mutational analysis.
Smith AE, Kulasekararaj AG, Jiang J, Mian S, Mohamedali A, Gaken J, Ireland R, Czepulkowski B, Best S, Mufti GJ. Smith AE, et al. Lancet Haematol. 2015 May;2(5):e212-21. doi: 10.1016/S2352-3026(15)00050-2. Epub 2015 May 6. Lancet Haematol. 2015. PMID: 26688096
FINDINGS: 39 (16%) of 250 patients with myeloid neoplasms had isolated del(5q), of whom seven (18%) had CSNK1A1 mutations. All these mutations were missense and presented in a highly conserved region that is implicated in ATP catalysis. ...INTERPRETATION: Sim …
FINDINGS: 39 (16%) of 250 patients with myeloid neoplasms had isolated del(5q), of whom seven (18%) had CSNK1A1 mutatio …
134 results