Format

Send to

Choose Destination

See 1 citation found using an alternative search:

Mol Immunol. 2009 Apr;46(7):1405-8. doi: 10.1016/j.molimm.2008.12.002. Epub 2009 Jan 21.

Is complement factor H a susceptibility factor for IgA nephropathy?

Author information

1
Institute of Human Genetics, Newcastle University, Newcastle upon Tyne, UK.

Abstract

There is substantial evidence to suggest that complement activation plays a pivotal role in the pathogenesis of IgA nephropathy. Mesangial C3 deposition is seen in approximately 90% of patients and polymeric IgA has been shown to activate the alternative and lectin pathways. In addition there have been reports of deficiency and mutations in the serum complement regulator factor H (CFH) in association with IgA nephropathy. In this study we have examined the hypothesis that CFH is a susceptibility factor for IgA nephropathy. In 46 IgA nephropathy patients we undertook genotyping of three CFH SNPS (rs3753394, rs3753396 and rs1065489). There was no significant difference in the allele frequency of these 3 SNPs between the patients and normal controls. In the same group of patients we undertook mutation screening of CFH exons 18-23 using direct sequencing and found no abnormalities. All the patients had a normal serum factor H concentration. In this small cohort of IgA nephropathy patients we have not found evidence to support the hypothesis that factor H is a major susceptibility factor for the disease.

PMID:
19162324
DOI:
10.1016/j.molimm.2008.12.002
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center