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Clin Infect Dis. 2015 Nov 1;61(9):1441-4. doi: 10.1093/cid/civ575. Epub 2015 Jul 17.

Intravenous Artesunate Reduces Parasite Clearance Time, Duration of Intensive Care, and Hospital Treatment in Patients With Severe Malaria in Europe: The TropNet Severe Malaria Study.

Author information

1
Medizinische Klinik mit Schwerpunkt Infektiologie und Pneumologie, Charité Universitätsmedizin Berlin, Germany.
2
Hôpital Saint-Antoine, Paris.
3
Section Tropical Medicine and Clinical International Health, Division of Infectious and Tropical Diseases, Department of Medicine, University Hospital Centre, Bordeaux, France.
4
Institute of Tropical Medicine, Antwerp, Belgium.
5
Department of Biomedical and Clinical Sciences L. Sacco, University of Milan, Italy.
6
Infectious Diseases Unit, Herlev University Hospital, Copenhagen, Denmark.
7
ISGlobal, Barcelona Centre for International Health Research, Spain.
8
National Centre for Tropical Infectious Diseases, Department of Medicine, Haukeland University Hospital, Bergen, Norway.
9
National Institute of Infectious Diseases Lazzaro Spallanzani, Rome, Italy.
10
Department of Medicine I, Division of Infectious Diseases and Tropical Medicine, Medical University of Vienna, Austria.
11
SOD Malattie Infettive e Tropicali, Azienda Ospedaliero Universitaria Careggi, Florence, Italy.
12
Department of Infectious Diseases, Leiden University Medical Centre, The Netherlands.
13
Department of Internal Medicine I, Section Tropical Medicine, University Medical Center Hamburg-Eppendorf Department of Clinical Research, Bernhard Nocht Institute for Tropical Medicine, Hamburg.
14
Institute of Public Health, University of Heidelberg Institute of Tropical Medicine, University of Tübingen, Germany.
15
Travel Medicine Unit, Department of Infectious Diseases, Amedeo di Savoia Hospital-ASLTO2, Turin, Italy.
16
Tropical Medicine Unit, Hospital de Poniente, El Ejido, Spain.
17
Department of Infectious Diseases, Aalborg University Hospital, Denmark.
18
Department of Internal Medicine II, Section Infectious diseases and Tropical Medicine, University Hospital Frankfurt/Main, Germany.
19
Swiss Tropical and Public Health Institute, Basel.
20
Department of Infectious Diseases, Bern University Hospital and University of Bern, Switzerland.
21
Department of Infection and Tropical Medicine, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom.
22
Clinica Luganese, Lugano, Switzerland.
23
Comprehensive Infectious Diseases Center, Department of Internal Medicine III, Ulm University Hospital, Germany.
24
Centro Hospitalar e Universitário de Coimbra, Portugal.
25
Hospital Universitari Joan XXIII, Tarragona, Spain.
26
Abteilung für Infektions- und Tropenmedizin, Medizinische Poliklinik, University of Munich, Germany.

Abstract

Intravenous artesunate improves survival in severe malaria, but clinical trial data from nonendemic countries are scarce. The TropNet severe malaria database was analyzed to compare outcomes of artesunate vs quinine treatment. Artesunate reduced parasite clearance time and duration of intensive care unit and hospital treatment in European patients with imported severe malaria.

KEYWORDS:

Plasmodium falciparum; artesunate; clinical study; quinine; severe malaria

PMID:
26187021
DOI:
10.1093/cid/civ575
[Indexed for MEDLINE]

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