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J Atheroscler Thromb. 2014;21(3):217-29. Epub 2013 Oct 12.

Intracoronary infusion of mononuclear bone marrow-derived stem cells is associated with a lower plaque burden after four years.

Author information

1
University of Medicine and Pharmacy Tirgu-Mures, Romania, Department of Internal Medicine, Clinic of Cardiology.

Abstract

AIM:

To assess the long-term effects of intracoronary stem cell (SC) infusion following acute myocardial infarction (AMI) on the local atherosclerotic process at the site of infusion after four years of follow-up.

METHODS:

We evaluated 18 post-AMI patients. Group 1 consisted of nine patients given an intracoronary injection of autologous mononuclear SC, and group 2 consisted of nine patients given a placebo injection. The plaque count, plaque burden (PB) and coronary calcium score (CCS) were assessed using multislice 64 CT angiography of the coronary tree four years after SC injection.

RESULTS:

The total PB and CCS along the entire coronary segment distal to the site of infusion were significantly lower in the SC group (PB-702 mm(3) vs. 1.465 mm(3), p=0.0006; CCS-295 vs. 796, p< 0.0001).The mean PB per coronary artery was 112.12 mm(3)±16.82 mm(3) for the treated arteries vs. 189.56 mm(3)±20.98 mm(3) for the untreated arteries (p<0.0001), while the mean CCS was 53.12±16.4 vs. 106.43±10.86 (p<0.0001). In the SC group, there were significant differences in the mean PB (87.75 mm(3) vs. 112.12 mm(2), p= 0.005) and mean CCS (36.87 vs. 53.12, p=0.04) between the coronary segment infused with SC and the entire coronary artery.

CONCLUSIONS:

Multislice CT angiography of atheromatous plaques in the coronary tree four years after SC infusion in post-AMI patients indicates a significantly lower atheromatous plaque burden, as demonstrated by a lower plaque volume and lower CCS at the site of stem cell infusion compared with other coronary territories.

PMID:
24126180
DOI:
10.5551/jat.19745
[Indexed for MEDLINE]
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