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Tissue Eng Part A. 2019 Mar;25(5-6):437-445. doi: 10.1089/ten.TEA.2018.0133. Epub 2018 Oct 3.

Integration Capacity of Human Induced Pluripotent Stem Cell-Derived Cartilage.

Author information

1
1 Cell Induction and Regulation Field, Department of Clinical Application, Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan.
2
2 Department of Life Science Frontiers, Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan.

Abstract

Cartilage particles derived from human induced pluripotent stem cells (hiPS-Carts) are one candidate source for transplants for treatment of articular cartilage damage. This study shows that hiPS-Carts integrate with each other in an in vitro model and analyzed the course of the integration. The integration starts at the perichondrium-like membrane at around 1 week and then progresses to the central cartilage within 4-8 weeks. The results indicate that FGF18 secreted from the perichondrium-like membrane accelerates the initial step of integration. The findings contribute to understanding how hiPS-Carts form repair tissue and provide clue to accelerate healing after transplantation.

KEYWORDS:

FGF; cartilage; chondrocyte; iPS cells; perichondrium

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