Format

Send to

Choose Destination

See 1 citation found by title matching your search:

Methods Mol Biol. 2015;1243:237-53. doi: 10.1007/978-1-4939-1872-0_14.

Integrating proteomics profiling data sets: a network perspective.

Author information

1
Mosaiques-Diagnostics GmbH, Mellendorfer Straße 7-9, D-30625, Hannover, Germany, bhat@mosaiques-diagnostics.com.

Abstract

Understanding disease mechanisms often requires complex and accurate integration of cellular pathways and molecular networks. Systems biology offers the possibility to provide a comprehensive map of the cell's intricate wiring network, which can ultimately lead to decipher the disease phenotype. Here, we describe what biological pathways are, how they function in normal and abnormal cellular systems, limitations faced by databases for integrating data, and highlight how network models are emerging as a powerful integrative framework to understand and interpret the roles of proteins and peptides in diseases.

PMID:
25384750
DOI:
10.1007/978-1-4939-1872-0_14
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center