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Insights From Analysis of Human Antigen-Specific Memory B Cell Repertoires.
Shah HB, Smith K, Wren JD, Webb CF, Ballard JD, Bourn RL, James JA, Lang ML. Shah HB, et al. Front Immunol. 2019 Jan 15;9:3064. doi: 10.3389/fimmu.2018.03064. eCollection 2018. Front Immunol. 2019. PMID: 30697210 Free PMC article. Review.
Single cell approaches coupled with next generation antibody gene sequencing facilitate a detailed analysis of the pathogen-specific memory B cell repertoire. Monoclonal antibodies that are generated from antibody gene sequences allow a function …
Single cell approaches coupled with next generation antibody gene sequencing facilitate a detailed analysis of the pathogen-specific …
Rapid isolation and immune profiling of SARS-CoV-2 specific memory B cell in convalescent COVID-19 patients via LIBRA-seq.
He B, Liu S, Wang Y, Xu M, Cai W, Liu J, Bai W, Ye S, Ma Y, Hu H, Meng H, Sun T, Li Y, Luo H, Shi M, Du X, Zhao W, Chen S, Yang J, Zhu H, Jie Y, Yang Y, Guo D, Wang Q, Liu Y, Yan H, Wang M, Chen YQ. He B, et al. Signal Transduct Target Ther. 2021 May 17;6(1):195. doi: 10.1038/s41392-021-00610-7. Signal Transduct Target Ther. 2021. PMID: 34001847 Free PMC article.
Via linking BCR to antigen specificity through sequencing (LIBRA-seq), we identified a distinct activated memory B cell subgroup (CD11c(high) CD95(high)) had a higher proportion of SARS-CoV-2 antigen-labeled cells compared with memory B cells …
Via linking BCR to antigen specificity through sequencing (LIBRA-seq), we identified a distinct activated memory B cell …
Tfh cell response in influenza vaccines in humans: what is visible and what is invisible.
Ueno H. Ueno H. Curr Opin Immunol. 2019 Aug;59:9-14. doi: 10.1016/j.coi.2019.02.007. Epub 2019 Mar 25. Curr Opin Immunol. 2019. PMID: 30921542 Free PMC article. Review.
Recently, influenza vaccination was shown to induce the expansion of two types of memory B cells in addition to plasmablasts. It is plausible that activated Tfh cells that remain in the lymph nodes after vaccination, a cell population missed in the analysi …
Recently, influenza vaccination was shown to induce the expansion of two types of memory B cells in addition to plasmab …
B cell receptor repertoire abnormalities in autoimmune disease.
Yuuki H, Itamiya T, Nagafuchi Y, Ota M, Fujio K. Yuuki H, et al. Front Immunol. 2024 Jan 31;15:1326823. doi: 10.3389/fimmu.2024.1326823. eCollection 2024. Front Immunol. 2024. PMID: 38361948 Free PMC article. Review.
Classically, BCR repertoire was used as an identifier of distinct antigen-specific clonotypes, but the recent advancement of analyzing large-scale repertoire has enabled us to use it as a tool for characterizing cellular biology. ...In systemic lupus e …
Classically, BCR repertoire was used as an identifier of distinct antigen-specific clonotypes, but the recent advanceme …
Memory B Cell Activation, Broad Anti-influenza Antibodies, and Bystander Activation Revealed by Single-Cell Transcriptomics.
Horns F, Dekker CL, Quake SR. Horns F, et al. Cell Rep. 2020 Jan 21;30(3):905-913.e6. doi: 10.1016/j.celrep.2019.12.063. Cell Rep. 2020. PMID: 31968262 Free PMC article.
Antibody memory protects humans from many diseases. Protective antibody memory responses require activation of transcriptional programs, cell proliferation, and production of antigen-specific antibodies, but how these aspects of the response are coordinated i …
Antibody memory protects humans from many diseases. Protective antibody memory responses require activation of transcriptional progra …