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Items: 9

1.

Novel Pyrimidines as Antitubercular Agents.

Inoyama D, Paget SD, Russo R, Kandasamy S, Kumar P, Singleton E, Occi J, Tuckman M, Zimmerman MD, Ho HP, Perryman AL, Dartois V, Connell N, Freundlich JS.

Antimicrob Agents Chemother. 2018 Feb 23;62(3). pii: e02063-17. doi: 10.1128/AAC.02063-17. Print 2018 Mar.

PMID:
29311070
2.

Human Microbiome Inspired Antibiotics with Improved β-Lactam Synergy against MDR Staphylococcus aureus.

Chu J, Vila-Farres X, Inoyama D, Gallardo-Macias R, Jaskowski M, Satish S, Freundlich JS, Brady SF.

ACS Infect Dis. 2018 Jan 12;4(1):33-38. doi: 10.1021/acsinfecdis.7b00056. Epub 2017 Sep 11.

PMID:
28845973
3.

Antimicrobials Inspired by Nonribosomal Peptide Synthetase Gene Clusters.

Vila-Farres X, Chu J, Inoyama D, Ternei MA, Lemetre C, Cohen LJ, Cho W, Reddy BV, Zebroski HA, Freundlich JS, Perlin DS, Brady SF.

J Am Chem Soc. 2017 Feb 1;139(4):1404-1407. doi: 10.1021/jacs.6b11861. Epub 2017 Jan 23.

PMID:
28055186
4.

Discovery of MRSA active antibiotics using primary sequence from the human microbiome.

Chu J, Vila-Farres X, Inoyama D, Ternei M, Cohen LJ, Gordon EA, Reddy BV, Charlop-Powers Z, Zebroski HA, Gallardo-Macias R, Jaskowski M, Satish S, Park S, Perlin DS, Freundlich JS, Brady SF.

Nat Chem Biol. 2016 Dec;12(12):1004-1006. doi: 10.1038/nchembio.2207. Epub 2016 Oct 17.

5.

The identification and characterization of non-reactive inhibitor of Keap1-Nrf2 interaction through HTS using a fluorescence polarization assay.

Wang L, Lewis T, Zhang YL, Khodier C, Magesh S, Chen L, Inoyama D, Chen Y, Zhen J, Hu L, Beamer LJ, Faloon PW, Dandapani S, Perez JR, Munoz B, Palmer M, Schreiber S.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2012 Dec 17 [updated 2013 Sep 16].

6.

Discovery of a small-molecule inhibitor and cellular probe of Keap1-Nrf2 protein-protein interaction.

Hu L, Magesh S, Chen L, Wang L, Lewis TA, Chen Y, Khodier C, Inoyama D, Beamer LJ, Emge TJ, Shen J, Kerrigan JE, Kong AN, Dandapani S, Palmer M, Schreiber SL, Munoz B.

Bioorg Med Chem Lett. 2013 May 15;23(10):3039-43. doi: 10.1016/j.bmcl.2013.03.013. Epub 2013 Mar 14.

7.

Optimization of fluorescently labeled Nrf2 peptide probes and the development of a fluorescence polarization assay for the discovery of inhibitors of Keap1-Nrf2 interaction.

Inoyama D, Chen Y, Huang X, Beamer LJ, Kong AN, Hu L.

J Biomol Screen. 2012 Apr;17(4):435-47. doi: 10.1177/1087057111430124. Epub 2011 Dec 7.

8.

Kinetic analyses of Keap1-Nrf2 interaction and determination of the minimal Nrf2 peptide sequence required for Keap1 binding using surface plasmon resonance.

Chen Y, Inoyama D, Kong AN, Beamer LJ, Hu L.

Chem Biol Drug Des. 2011 Dec;78(6):1014-21. doi: 10.1111/j.1747-0285.2011.01240.x. Epub 2011 Oct 31.

9.

The intrinsic conformational propensities of the 20 naturally occurring amino acids and reflection of these propensities in proteins.

Beck DA, Alonso DO, Inoyama D, Daggett V.

Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12259-64. doi: 10.1073/pnas.0706527105. Epub 2008 Aug 19.

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