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J Virol. 2014 Nov;88(21):12910-4. doi: 10.1128/JVI.02107-14. Epub 2014 Aug 13.

Inhibition of breast cancer cell proliferation through disturbance of the calcineurin/NFAT pathway by human herpesvirus 6B U54 tegument protein.

Author information

1
Division of Infectious and Immune Diseases, CHU de Quebec Research Center, Quebec, Canada.
2
Division of Infectious and Immune Diseases, CHU de Quebec Research Center, Quebec, Canada Department of Microbiology, Infectious Diseases and Immunology, Faculty of Medicine, Laval University, Quebec, Canada Louis.flamand@crchul.ulaval.ca.

Abstract

Nuclear factor of activated T cell (NFAT) proteins are key regulators involved in multiple physiological mechanisms, such as immune response and cell growth. The capacity of selective calcineurin/NFAT inhibitors to decrease NFAT-dependent cancer cell progression, particularly in breast cancer, has already been demonstrated. In this study, we report a role for the human herpesvirus 6B (HHV-6B) U54 tegument protein in inhibiting MCF-7 breast cancer cell proliferation by inhibiting NFAT activation.

PMID:
25122795
PMCID:
PMC4248891
DOI:
10.1128/JVI.02107-14
[Indexed for MEDLINE]
Free PMC Article

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