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16 results

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Page 1
Inducing and exploiting vulnerabilities for the treatment of liver cancer.
Wang C, Vegna S, Jin H, Benedict B, Lieftink C, Ramirez C, de Oliveira RL, Morris B, Gadiot J, Wang W, du Chatinier A, Wang L, Gao D, Evers B, Jin G, Xue Z, Schepers A, Jochems F, Sanchez AM, Mainardi S, Te Riele H, Beijersbergen RL, Qin W, Akkari L, Bernards R. Wang C, et al. Nature. 2019 Oct;574(7777):268-272. doi: 10.1038/s41586-019-1607-3. Epub 2019 Oct 2. Nature. 2019. PMID: 31578521 Free PMC article.
Here, using a kinome-focused genetic screen, we show that pharmacological inhibition of the DNA-replication kinase CDC7 induces senescence selectively in liver cancer cells with mutations in TP53. ...Our data indicate that exploiting an induced …
Here, using a kinome-focused genetic screen, we show that pharmacological inhibition of the DNA-replication kinase CDC7 induces senes …
Blocking methionine catabolism induces senescence and confers vulnerability to GSK3 inhibition in liver cancer.
Li F, Liu P, Mi W, Li L, Anderson NM, Lesner NP, Burrows M, Plesset J, Majer A, Wang G, Li J, Zhu L, Keith B, Simon MC. Li F, et al. Nat Cancer. 2024 Jan;5(1):131-146. doi: 10.1038/s43018-023-00671-3. Epub 2024 Jan 2. Nat Cancer. 2024. PMID: 38168934
Blocking methionine adenosyl transferase 2A (MAT2A)-dependent methionine catabolism induces cell cycle arrest and DNA damage in liver cancer cells, resulting in cellular senescence. ...Together, methionine catabolism is essential for liver tumor growth …
Blocking methionine adenosyl transferase 2A (MAT2A)-dependent methionine catabolism induces cell cycle arrest and DNA damage in li …
Hexokinase-2 depletion inhibits glycolysis and induces oxidative phosphorylation in hepatocellular carcinoma and sensitizes to metformin.
DeWaal D, Nogueira V, Terry AR, Patra KC, Jeon SM, Guzman G, Au J, Long CP, Antoniewicz MR, Hay N. DeWaal D, et al. Nat Commun. 2018 Jan 31;9(1):446. doi: 10.1038/s41467-017-02733-4. Nat Commun. 2018. PMID: 29386513 Free PMC article.
Hepatocellular carcinoma (HCC) cells are metabolically distinct from normal hepatocytes by expressing the high-affinity hexokinase (HK2) and suppressing glucokinase (GCK). This is exploited to selectively target HCC. Hepatic HK2 deletion inhibits tumor incidence in a mouse …
Hepatocellular carcinoma (HCC) cells are metabolically distinct from normal hepatocytes by expressing the high-affinity hexokinase (HK2) and …
Aneuploidy: Cancer strength or vulnerability?
Simonetti G, Bruno S, Padella A, Tenti E, Martinelli G. Simonetti G, et al. Int J Cancer. 2019 Jan 1;144(1):8-25. doi: 10.1002/ijc.31718. Epub 2018 Oct 31. Int J Cancer. 2019. PMID: 29981145 Free PMC article. Review.
Aneuploidy is a very rare and tissue-specific event in normal conditions, occurring in a low number of brain and liver cells. Its frequency increases in age-related disorders and is one of the hallmarks of cancer. ...Indeed, promising results have been obtained from …
Aneuploidy is a very rare and tissue-specific event in normal conditions, occurring in a low number of brain and liver cells. Its fre …
LKB1: Can We Target an Hidden Target? Focus on NSCLC.
Ndembe G, Intini I, Perin E, Marabese M, Caiola E, Mendogni P, Rosso L, Broggini M, Colombo M. Ndembe G, et al. Front Oncol. 2022 May 11;12:889826. doi: 10.3389/fonc.2022.889826. eCollection 2022. Front Oncol. 2022. PMID: 35646638 Free PMC article. Review.
LKB1 loss leads to an enhanced metabolic avidity, and treatments inducing metabolic stress were successful in inhibiting tumor growth in several preclinical models. ...Nutrient deprivation has been investigated as an alternative therapeutic intervention, giving rise …
LKB1 loss leads to an enhanced metabolic avidity, and treatments inducing metabolic stress were successful in inhibiting tumor …
Cancer cell genetics shaping of the tumor microenvironment reveals myeloid cell-centric exploitable vulnerabilities in hepatocellular carcinoma.
Ramirez CFA, Taranto D, Ando-Kuri M, de Groot MHP, Tsouri E, Huang Z, de Groot D, Kluin RJC, Kloosterman DJ, Verheij J, Xu J, Vegna S, Akkari L. Ramirez CFA, et al. Nat Commun. 2024 Mar 22;15(1):2581. doi: 10.1038/s41467-024-46835-2. Nat Commun. 2024. PMID: 38519484 Free PMC article.
Yet several aspects underlying their dynamic alterations in hepatocellular carcinoma (HCC) progression remain elusive, including the impact of distinct genetic mutations in shaping a cancer-permissive tumor microenvironment (TME). Here, in newly generated, clinically-relev …
Yet several aspects underlying their dynamic alterations in hepatocellular carcinoma (HCC) progression remain elusive, including the impact …
Genome-Wide CRISPR-Cas9 Screen Reveals Selective Vulnerability of ATRX-Mutant Cancers to WEE1 Inhibition.
Liang J, Zhao H, Diplas BH, Liu S, Liu J, Wang D, Lu Y, Zhu Q, Wu J, Wang W, Yan H, Zeng YX, Wang X, Jiao Y. Liang J, et al. Cancer Res. 2020 Feb 1;80(3):510-523. doi: 10.1158/0008-5472.CAN-18-3374. Epub 2019 Sep 24. Cancer Res. 2020. PMID: 31551363
The tumor suppressor gene ATRX is frequently mutated in a variety of tumors including gliomas and liver cancers, which are highly unresponsive to current therapies. ...The increased sensitivity to the WEE1 inhibitor was caused by accumulated DNA damage-induced apopt …
The tumor suppressor gene ATRX is frequently mutated in a variety of tumors including gliomas and liver cancers, which are highly unr …
Interrogation of Folic Acid-Functionalized Nanomedicines: The Regulatory Roles of Plasma Proteins Reexamined.
Wang H, Ding T, Guan J, Liu X, Wang J, Jin P, Hou S, Lu W, Qian J, Wang W, Zhan C. Wang H, et al. ACS Nano. 2020 Nov 24;14(11):14779-14789. doi: 10.1021/acsnano.0c02821. Epub 2020 Oct 21. ACS Nano. 2020. PMID: 33084315
Folic acid (FA) has been extensively exploited to facilitate targeted delivery of nanomedicines by recognizing the folate receptor-alpha (FR-alpha) overexpressed in many human cancers. ...FA functionalization does not enhance distribution of liposomes in FR-alpha-overexpre …
Folic acid (FA) has been extensively exploited to facilitate targeted delivery of nanomedicines by recognizing the folate receptor-al …
Gamma delta T-cell reconstitution after allogeneic HCT: A platform for cell therapy.
Gaballa A, Arruda LCM, Uhlin M. Gaballa A, et al. Front Immunol. 2022 Aug 29;13:971709. doi: 10.3389/fimmu.2022.971709. eCollection 2022. Front Immunol. 2022. PMID: 36105821 Free PMC article. Review.
Despite its therapeutic benefits, the profound immunodeficiency associated with the transplant procedure remains a major challenge that renders patients vulnerable to several complications. Today, It is well established that a rapid and efficient immune reconstitution, par …
Despite its therapeutic benefits, the profound immunodeficiency associated with the transplant procedure remains a major challenge that rend …
The Cationic Amphiphilic Drug Hexamethylene Amiloride Eradicates Bulk Breast Cancer Cells and Therapy-Resistant Subpopulations with Similar Efficiencies.
Berg AL, Rowson-Hodel A, Hu M, Keeling M, Wu H, VanderVorst K, Chen JJ, Hatakeyama J, Jilek J, Dreyer CA, Wheeler MR, Yu AM, Li Y, Carraway KL 3rd. Berg AL, et al. Cancers (Basel). 2022 Feb 14;14(4):949. doi: 10.3390/cancers14040949. Cancers (Basel). 2022. PMID: 35205696 Free PMC article.
The resistance of cancer cell subpopulations, including cancer stem cell (CSC) populations, to apoptosis-inducing chemotherapeutic agents is a key barrier to improved outcomes for cancer patients. ...Our observations expose a key vulnerability i …
The resistance of cancer cell subpopulations, including cancer stem cell (CSC) populations, to apoptosis-inducing chemo …
16 results