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J Ocul Pharmacol Ther. 2016 Jun;32(5):240-52. doi: 10.1089/jop.2015.0143. Epub 2016 Mar 30.

Induced Pluripotent Stem Cell Therapies for Degenerative Disease of the Outer Retina: Disease Modeling and Cell Replacement.

Author information

1
1 UCL Institute of Child Health, University College London , London, United Kingdom .
2
2 UCL Institute of Ophthalmology , London, United Kingdom .

Abstract

Stem cell therapies are being explored as potential treatments for retinal disease. How to replace neurons in a degenerated retina presents a continued challenge for the regenerative medicine field that, if achieved, could restore sight. The major issues are: (i) the source and availability of donor cells for transplantation; (ii) the differentiation of stem cells into the required retinal cells; and (iii) the delivery, integration, functionality, and survival of new cells in the host neural network. This review considers the use of induced pluripotent stem cells (iPSC), currently under intense investigation, as a platform for cell transplantation therapy. Moreover, patient-specific iPSC are being developed for autologous cell transplantation and as a tool for modeling specific retinal diseases, testing gene therapies, and drug screening.

PMID:
27027805
PMCID:
PMC4904163
DOI:
10.1089/jop.2015.0143
[Indexed for MEDLINE]
Free PMC Article

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