Format

Send to

Choose Destination

See 1 citation found by title matching your search:

United European Gastroenterol J. 2017 Jun;5(4):473-478. doi: 10.1177/2050640616671643. Epub 2016 Sep 21.

Increased risk for metachronous gastric adenocarcinoma following gastric MALT lymphoma-A US population-based study.

Author information

1
Department of Gastroenterology, Hospital Beatriz Ângelo, Loures, Portugal.
2
Department of Ophthalmology, Centro Hospitalar e Universitário de Coimbra, EPE, Coimbra, Portugal.
3
Department of Cardiology, Centro Hospitalar de Vila Nova de Gaia/Espinho, EPE, Vila Nova de Gaia, Portugal.
4
Department of Pediatrics, Centro Hospitalar Lisboa Central, EPE, Lisboa, Portugal.
5
ACES Lisboa Norte, Lisboa, Portugal.

Abstract

BACKGROUND:

Gastric mucosa-associated lymphoid tissue lymphoma (gMALT) and gastric adenocarcinoma (GC) are long-term complications of chronic Helicobacter pylori (HP) gastritis. Treatment of HP infection induces remission in most patients with gMALT. Endoscopic follow-up is not currently endorsed after complete remission. However, the risk of GC in these patients is unclear.

OBJECTIVE:

The objective of this study is to estimate GC risk in gMALT patients.

METHODS:

The National Cancer Institute Surveillance, Epidemiology and End Results 13 (SEER) database-Nov 2014 Sub (1992-2012) was used to identify adult patients diagnosed with gMALT between 1992 and 2012. The standardized incidence ratio of second primary GC after a latency period of 12 months was calculated and compared to a reference SEER cohort of identical age, sex and time period. The risk of GC in these patients was also stratified by latency period (five years) and age.

RESULTS:

We identified 2195 cases of gMALT lymphoma, and 20 (0.91%) of them subsequently developed GC with a relative risk (RR) of 4.32 (95% CI 2.64-6.67) compared to the American population. The median latency time was five years and the risk was maintained afterward (RR 4.92, 95% CI 2.45-8.79). When stratified by age group the risk was highest for the 45-64 group (RR 14.04, 95% CI 5.64-28.93).

CONCLUSION:

gMALT lymphoma is associated with an increased risk of metachronous gastric adenocarcinoma. The risk is still present after more than five years of follow-up. Further studies may clarify the most adequate follow-up strategy.

KEYWORDS:

Gastric MALT lymphoma; Helicobacter pylori; follow-up studies; gastric adenocarcinoma; metachronous cancer risk

Supplemental Content

Full text links

Icon for PubMed Central
Loading ...
Support Center