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Oncol Rep. 2007 Apr;17(4):713-9.

Increased BRCA1 protein in mammary tumours of rats fed marine omega-3 fatty acids.

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INSERM, E 0211; Université François Rabelais; CHU Bretonneau, Tours, F-37000, France.


Any factor affecting BRCA gene regulation may be of interest in the prevention of breast tumourigenesis. We studied the influence of dietary docosahexaenoic acid (DHA), a major omega-3 fatty acid present in marine products, on rat autochthonous mammary tumourigenesis. DHA-supplementation significantly reduced the incidence of tumours (30%, P=0.007) and led to a 60% increase (P=0.02) in BRCA1 protein level. Since DHA influences the product of a major tumour suppressor gene, this finding may contribute to the observation that high-fish consumption reduces the risk of breast cancer.

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