Send to

Choose Destination

See 1 citation found by title matching your search:

Cell Tissue Res. 2012 Jun;348(3):465-73. doi: 10.1007/s00441-012-1379-7. Epub 2012 Mar 17.

In-vitro regulation of odontogenic gene expression in human embryonic tooth cells and SHED cells.

Author information

BioNec, Section of Histology and Embryology, Faculty of Medicine, University of Palermo, Palermo, Italy.


The bud-to-cap stage transition during early tooth development is a time when the tooth-inducing potential becomes restricted to the mesenchyme. Several key genes, expressed in the mesenchyme at this stage, are an absolute requirement for the progression of tooth development. These include the transcription factors Msx1 and Pax9. The inductive potential of tooth mesenchyme cells is a key requisite for whole-tooth bioengineering and thus identification of cells that can retain this property following expansion in culture is an important as yet unresolved, goal. We show here that in-vitro culture of embryonic human tooth mesenchyme cells and SHED cells express low levels of PAX9 and MSX1 and that these levels can be significantly upregulated by activation of different signalling pathways. Such in-vitro manipulation may thus offer a simple way of maintaining/restoring/inducing the odontogenic-inducing capacity in mesenchymal cells.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center