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J Biomed Mater Res A. 2014 May;102(5):1316-24. doi: 10.1002/jbm.a.34808. Epub 2013 Jun 7.

In vitro biocompatibility of Ti-45S5 bioglass nanocomposites and their scaffolds.

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Department of Immunology, Poznan University of Medical Sciences, Rokietnicka 5D, 60-806, Poznan, Poland.


Titanium-10 wt % 45S5 Bioglass nanocomposites and their scaffolds were prepared by mechanical alloying (MA) followed by pressing, sintering, or combination of MA and a "space-holder" sintering process, respectively. An amorphous structure was obtained at 15 h of milling. The crystallization of the amorphous phase upon annealing led to the formation of a nanostructured Ti-10 wt % 45S5 Bioglass composite with a grain size of approximately 7 nm. The in vitro cytocompatibility of these materials was evaluated and compared with a conventional microcrystalline titanium. During the studies, established cell line of human fibroblasts CCD-39Lu was cultured in the presence of tested materials and its survival rate, and proliferation activity were examined. Furthermore, the influence of the Ti-45S5 Bioglass nanocomposites and microcrystalline titanium was tested on the growth of Candida albicans yeast. Biocompatibility tests carried out indicate that the nanocomposite Ti-10 wt % 45S5 Bioglass scaffolds could be a possible candidate for dental implants and other medicinal applications.


bioglass; cell proliferation; cell viability; nanocomposite; scaffold

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