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Clin Infect Dis. 2016 Aug 15;63(4):519-27. doi: 10.1093/cid/ciw354. Epub 2016 May 26.

Impact and Effectiveness of the Quadrivalent Human Papillomavirus Vaccine: A Systematic Review of 10 Years of Real-world Experience.

Author information

1
Royal Women's Hospital, University of Melbourne, Murdoch Childrens Research Institute, Victoria, Australia.
2
Danish Cancer Society Research Center and Department of Gynecology, Rigshospitalet, University of Copenhagen, Denmark.
3
Colombian National Institute of Cancer, Bogota.
4
Kentucky Pediatric and Adult Research, Bardstown.
5
Indiana University School of Medicine, Indianapolis.
6
Merck & Co, Inc, Kenilworth, New Jersey.
7
Merck & Co, Inc, Kenilworth, New Jersey Universidad del Rosario, Bogota, Colombia.
8
Sanofi Pasteur MSD, Lyon, France.

Abstract

Prophylactic human papillomavirus (HPV) vaccination programs constitute major public health initiatives worldwide. We assessed the global effect of quadrivalent HPV (4vHPV) vaccination on HPV infection and disease. PubMed and Embase were systematically searched for peer-reviewed articles from January 2007 through February 2016 to identify observational studies reporting the impact or effectiveness of 4vHPV vaccination on infection, anogenital warts, and cervical cancer or precancerous lesions. Over the last decade, the impact of HPV vaccination in real-world settings has become increasingly evident, especially among girls vaccinated before HPV exposure in countries with high vaccine uptake. Maximal reductions of approximately 90% for HPV 6/11/16/18 infection, approximately 90% for genital warts, approximately 45% for low-grade cytological cervical abnormalities, and approximately 85% for high-grade histologically proven cervical abnormalities have been reported. The full public health potential of HPV vaccination is not yet realized. HPV-related disease remains a significant source of morbidity and mortality in developing and developed nations, underscoring the need for HPV vaccination programs with high population coverage.

KEYWORDS:

CIN; Gardasil/Silgard; HPV vaccination; cervical cancer; genital warts

PMID:
27230391
PMCID:
PMC4967609
DOI:
10.1093/cid/ciw354
[Indexed for MEDLINE]
Free PMC Article

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