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Items: 1 to 20 of 22


Effect of H2 treatment in a mouse model of rheumatoid arthritis-associated interstitial lung disease.

Terasaki Y, Terasaki M, Kanazawa S, Kokuho N, Urushiyama H, Kajimoto Y, Kunugi S, Maruyama M, Akimoto T, Miura Y, Igarashi T, Ohsawa I, Shimizu A.

J Cell Mol Med. 2019 Oct;23(10):7043-7053. doi: 10.1111/jcmm.14603. Epub 2019 Aug 19.


The N-terminal region of RTP1S plays important roles in dimer formation and odorant receptor-trafficking.

Fukutani Y, Tamaki R, Inoue R, Koshizawa T, Sakashita S, Ikegami K, Ohsawa I, Matsunami H, Yohda M.

J Biol Chem. 2019 Oct 4;294(40):14661-14673. doi: 10.1074/jbc.RA118.007110. Epub 2019 Aug 8.


Anticancer saponin OSW-1 is a novel class of selective Golgi stress inducer.

Kimura M, Sasaki K, Fukutani Y, Yoshida H, Ohsawa I, Yohda M, Sakurai K.

Bioorg Med Chem Lett. 2019 Jul 15;29(14):1732-1736. doi: 10.1016/j.bmcl.2019.05.022. Epub 2019 May 15.


Effects of Hydrogen in Prevention of Corneal Endothelial Damage During Phacoemulsification: A Prospective Randomized Clinical Trial.

Igarashi T, Ohsawa I, Kobayashi M, Umemoto Y, Arima T, Suzuki H, Igarashi T, Otsuka T, Takahashi H.

Am J Ophthalmol. 2019 Nov;207:10-17. doi: 10.1016/j.ajo.2019.04.014. Epub 2019 May 9.


Molecular hydrogen attenuates gefitinib-induced exacerbation of naphthalene-evoked acute lung injury through a reduction in oxidative stress and inflammation.

Terasaki Y, Suzuki T, Tonaki K, Terasaki M, Kuwahara N, Ohsiro J, Iketani M, Takahashi M, Hamanoue M, Kajimoto Y, Hattori S, Kawaguchi H, Shimizu A, Ohsawa I.

Lab Invest. 2019 Jun;99(6):793-806. doi: 10.1038/s41374-019-0187-z. Epub 2019 Feb 1.


Administration of hydrogen-rich water prevents vascular aging of the aorta in LDL receptor-deficient mice.

Iketani M, Sekimoto K, Igarashi T, Takahashi M, Komatsu M, Sakane I, Takahashi H, Kawaguchi H, Ohtani-Kaneko R, Ohsawa I.

Sci Rep. 2018 Nov 14;8(1):16822. doi: 10.1038/s41598-018-35239-0.


In vitro rejuvenation of brain mitochondria by the inhibition of actin polymerization.

Takahashi K, Miura Y, Ohsawa I, Shirasawa T, Takahashi M.

Sci Rep. 2018 Oct 22;8(1):15585. doi: 10.1038/s41598-018-34006-5.


Effects of Molecular Hydrogen Assessed by an Animal Model and a Randomized Clinical Study on Mild Cognitive Impairment.

Nishimaki K, Asada T, Ohsawa I, Nakajima E, Ikejima C, Yokota T, Kamimura N, Ohta S.

Curr Alzheimer Res. 2018 Mar 14;15(5):482-492. doi: 10.2174/1567205014666171106145017.


Optic atrophy 1 mediates coenzyme Q-responsive regulation of respiratory complex IV activity in brain mitochondria.

Takahashi K, Ohsawa I, Shirasawa T, Takahashi M.

Exp Gerontol. 2017 Nov;98:217-223. doi: 10.1016/j.exger.2017.09.002. Epub 2017 Sep 7.


Molecular hydrogen protects against oxidative stress-induced SH-SY5Y neuroblastoma cell death through the process of mitohormesis.

Murakami Y, Ito M, Ohsawa I.

PLoS One. 2017 May 3;12(5):e0176992. doi: 10.1371/journal.pone.0176992. eCollection 2017.


Preadministration of Hydrogen-Rich Water Protects Against Lipopolysaccharide-Induced Sepsis and Attenuates Liver Injury.

Iketani M, Ohshiro J, Urushibara T, Takahashi M, Arai T, Kawaguchi H, Ohsawa I.

Shock. 2017 Jul;48(1):85-93. doi: 10.1097/SHK.0000000000000810.


Hydrogen prevents corneal endothelial damage in phacoemulsification cataract surgery.

Igarashi T, Ohsawa I, Kobayashi M, Igarashi T, Suzuki H, Iketani M, Takahashi H.

Sci Rep. 2016 Aug 8;6:31190. doi: 10.1038/srep31190.


Molecular Hydrogen as a Neuroprotective Agent.

Iketani M, Ohsawa I.

Curr Neuropharmacol. 2017;15(2):324-331. Review.


Early-onset motor impairment and increased accumulation of phosphorylated α-synuclein in the motor cortex of normal aging mice are ameliorated by coenzyme Q.

Takahashi K, Ohsawa I, Shirasawa T, Takahashi M.

Exp Gerontol. 2016 Aug;81:65-75. doi: 10.1016/j.exger.2016.04.023. Epub 2016 Apr 30.


Hydrogen Gas Ameliorates Hepatic Reperfusion Injury After Prolonged Cold Preservation in Isolated Perfused Rat Liver.

Shimada S, Wakayama K, Fukai M, Shimamura T, Ishikawa T, Fukumori D, Shibata M, Yamashita K, Kimura T, Todo S, Ohsawa I, Taketomi A.

Artif Organs. 2016 Dec;40(12):1128-1136. doi: 10.1111/aor.12710. Epub 2016 May 2.


STED super-resolution imaging of mitochondria labeled with TMRM in living cells.

Ishigaki M, Iketani M, Sugaya M, Takahashi M, Tanaka M, Hattori S, Ohsawa I.

Mitochondrion. 2016 May;28:79-87. doi: 10.1016/j.mito.2016.03.009. Epub 2016 Apr 25.


Cell-permeable p38 MAP kinase promotes migration of adult neural stem/progenitor cells.

Hamanoue M, Morioka K, Ohsawa I, Ohsawa K, Kobayashi M, Tsuburaya K, Akasaka Y, Mikami T, Ogata T, Takamatsu K.

Sci Rep. 2016 Apr 12;6:24279. doi: 10.1038/srep24279.


Stimulation of human damaged sperm motility with hydrogen molecule.

Nakata K, Yamashita N, Noda Y, Ohsawa I.

Med Gas Res. 2015 Jan 10;5(1):2. doi: 10.1186/s13618-014-0023-x. eCollection 2015.


Extended lifespan, reduced body size and leg skeletal muscle mass, and decreased mitochondrial function in clk-1 transgenic mice.

Takahashi K, Noda Y, Ohsawa I, Shirasawa T, Takahashi M.

Exp Gerontol. 2014 Oct;58:146-53. doi: 10.1016/j.exger.2014.08.003. Epub 2014 Aug 6.


Oral administration of inosine produces antidepressant-like effects in mice.

Muto J, Lee H, Lee H, Uwaya A, Park J, Nakajima S, Nagata K, Ohno M, Ohsawa I, Mikami T.

Sci Rep. 2014 Feb 26;4:4199. doi: 10.1038/srep04199.

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