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J Clin Microbiol. 2014 Sep;52(9):3462-4. doi: 10.1128/JCM.01082-14. Epub 2014 Jun 25.

Identification of occult Fusobacterium nucleatum central nervous system infection by use of PCR-electrospray ionization mass spectrometry.

Author information

1
Department of Medicine, Division of Infectious Disease and HIV Medicine, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, Ohio, USA.
2
Department of Pathology, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, Ohio, USA.
3
Department of Medicine, Division of Infectious Disease and HIV Medicine, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, Ohio, USA Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA.
4
Infectious Diseases Pathology Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
5
Department of Medicine, University of Illinois School of Medicine, Peoria, Illinois, USA.
6
Ibis Biosciences, an Abbott Company, Carlsbad, California, USA.
7
Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA Departments of Pharmacology, Microbiology and Molecular Biology, Case Western Reserve University, Cleveland, Ohio, USA Robert.bonomo@va.gov.

Abstract

Anaerobic bacteria are often difficult to detect, especially after the initiation of antibiotics. We describe the application of PCR-electrospray ionization mass spectrometry (PCR/ESI-MS) using a sample of cerebrospinal fluid to identify an anaerobic Gram-negative bacillus, Fusobacterium nucleatum, in a patient with "culture-negative" meningitis and cerebral abscesses.

PMID:
24966358
PMCID:
PMC4313185
DOI:
10.1128/JCM.01082-14
[Indexed for MEDLINE]
Free PMC Article

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