Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2001 4
2002 1
2004 1
2006 2
2007 1
2008 1
2009 3
2010 2
2011 3
2012 3
2013 2
2014 6
2015 8
2016 7
2017 8
2018 5
2019 9
2020 8
2021 6
2022 10
2023 9
2024 4

Text availability

Article attribute

Article type

Publication date

Search Results

95 results

Results by year

Filters applied: . Clear all
Page 1
Circulating apelin, IL22RA2 and VEGF in pre-capillary pulmonary hypertension.
Csósza G, Szűcs G, Rozgonyi Z, Csoma B, Losonczy G, Müller V, Karlócai K, Lázár Z. Csósza G, et al. Physiol Int. 2023 Nov 17;110(4):356-370. doi: 10.1556/2060.2023.00264. Print 2023 Dec 18. Physiol Int. 2023. PMID: 37975916
Apelin concentration >1,261 ng/mL identified patients with PH (66% sensitivity and 82% specificity), and in patients it was related to systolic pulmonary arterial pressure (PAP) (r = 0.33, P = 0.04), right atrial pressure (r = 0.38, P = 0.02), cardiac index (r = -0.34, P = 0.0 …
Apelin concentration >1,261 ng/mL identified patients with PH (66% sensitivity and 82% specificity), and in patients it was related to sy …
Blocking Dectin-1 prevents colorectal tumorigenesis by suppressing prostaglandin E2 production in myeloid-derived suppressor cells and enhancing IL-22 binding protein expression.
Tang C, Sun H, Kadoki M, Han W, Ye X, Makusheva Y, Deng J, Feng B, Qiu D, Tan Y, Wang X, Guo Z, Huang C, Peng S, Chen M, Adachi Y, Ohno N, Trombetta S, Iwakura Y. Tang C, et al. Nat Commun. 2023 Mar 17;14(1):1493. doi: 10.1038/s41467-023-37229-x. Nat Commun. 2023. PMID: 36932082 Free PMC article.
In the Clec7a(-/-) mouse colon, the proportion of MDSCs and MDSC-derived prostaglandin E(2) (PGE(2)) levels are reduced, while the expression of IL-22 binding protein (IL-22BP; gene Il22ra2) is upregulated. Dectin-1 signaling induces PGE(2)-synthesizing enzymes and PGE(2) …
In the Clec7a(-/-) mouse colon, the proportion of MDSCs and MDSC-derived prostaglandin E(2) (PGE(2)) levels are reduced, while the expressio …
The Rare IL22RA2 Signal Peptide Coding Variant rs28385692 Decreases Secretion of IL-22BP Isoform-1, -2 and -3 and Is Associated with Risk for Multiple Sclerosis.
Gómez-Fernández P, Lopez de Lapuente Portilla A, Astobiza I, Mena J, Urtasun A, Altmann V, Matesanz F, Otaegui D, Urcelay E, Antigüedad A, Malhotra S, Montalban X, Castillo-Triviño T, Espino-Paisán L, Aktas O, Buttmann M, Chan A, Fontaine B, Gourraud PA, Hecker M, Hoffjan S, Kubisch C, Kümpfel T, Luessi F, Zettl UK, Zipp F, Alloza I, Comabella M, Lill CM, Vandenbroeck K. Gómez-Fernández P, et al. Cells. 2020 Jan 10;9(1):175. doi: 10.3390/cells9010175. Cells. 2020. PMID: 31936765 Free PMC article.
The IL22RA2 locus is associated with risk for multiple sclerosis (MS) but causative variants are yet to be determined. ...This variant is located in the signal peptide (SP) shared by the three secreted protein isoforms produced by IL22RA2 (IL-22 binding protein-1(IL …
The IL22RA2 locus is associated with risk for multiple sclerosis (MS) but causative variants are yet to be determined. ...This varian …
The multiple sclerosis risk gene IL22RA2 contributes to a more severe murine autoimmune neuroinflammation.
Laaksonen H, Guerreiro-Cacais AO, Adzemovic MZ, Parsa R, Zeitelhofer M, Jagodic M, Olsson T. Laaksonen H, et al. Genes Immun. 2014 Oct;15(7):457-65. doi: 10.1038/gene.2014.36. Epub 2014 Jul 10. Genes Immun. 2014. PMID: 25008863
Single-nucleotide polymorphisms close to IL22RA2, coding for the soluble interleukin (IL)-22-binding protein (IL-22BP), are strongly and reproducibly associated with multiple sclerosis (MS), but there is little data on how this molecule may affect neuroinflammation. Here, …
Single-nucleotide polymorphisms close to IL22RA2, coding for the soluble interleukin (IL)-22-binding protein (IL-22BP), are strongly …
Assessment of microRNA-related SNP effects in the 3' untranslated region of the IL22RA2 risk locus in multiple sclerosis.
Lill CM, Schilling M, Ansaloni S, Schröder J, Jaedicke M, Luessi F, Schjeide BM, Mashychev A, Graetz C, Akkad DA, Gerdes LA, Kroner A, Blaschke P, Hoffjan S, Winkelmann A, Dörner T, Rieckmann P, Steinhagen-Thiessen E, Lindenberger U, Chan A, Hartung HP, Aktas O, Lohse P, Buttmann M, Kümpfel T, Kubisch C, Zettl UK, Epplen JT, Zipp F, Bertram L. Lill CM, et al. Neurogenetics. 2014 May;15(2):129-34. doi: 10.1007/s10048-014-0396-y. Epub 2014 Mar 18. Neurogenetics. 2014. PMID: 24638856
One of these MS risk variants is single-nucleotide polymorphism (SNP) rs17066096, located ~14 kb downstream of IL22RA2. IL22RA2 represents a compelling MS candidate gene due to the role of IL-22 in autoimmunity; however, rs17066096 does not map into any known functi …
One of these MS risk variants is single-nucleotide polymorphism (SNP) rs17066096, located ~14 kb downstream of IL22RA2. IL22RA2 …
IL-22RA2 Is a SMAD7 Target Mediating the Alleviation of Dermatitis and Psoriatic Phenotypes in Mice.
Ke Y, Li BZ, Nguyen K, Wang D, Wang S, Young CD, Wang XJ. Ke Y, et al. J Invest Dermatol. 2023 Nov;143(11):2243-2254.e10. doi: 10.1016/j.jid.2023.04.029. Epub 2023 May 19. J Invest Dermatol. 2023. PMID: 37211203
Mechanistically, SMAD7 facilitated nuclear translocation and DNA binding of C/EBPbeta to IL22RA2 promoter for IL22RA2 transactivation. Consistent with the observations in mice mentioned earlier, transcript levels of IL22RA2 were increased in human atopic derm …
Mechanistically, SMAD7 facilitated nuclear translocation and DNA binding of C/EBPbeta to IL22RA2 promoter for IL22RA2 transact …
Interleukin-22 (IL-22) Binding Protein Constrains IL-22 Activity, Host Defense, and Oxidative Phosphorylation Genes during Pneumococcal Pneumonia.
Trevejo-Nunez G, Elsegeiny W, Aggor FEY, Tweedle JL, Kaplan Z, Gandhi P, Castillo P, Ferguson A, Alcorn JF, Chen K, Kolls JK, Gaffen SL. Trevejo-Nunez G, et al. Infect Immun. 2019 Oct 18;87(11):e00550-19. doi: 10.1128/IAI.00550-19. Print 2019 Nov. Infect Immun. 2019. PMID: 31451621 Free PMC article.
Here, we show that Il22ra2 inhibits IL-22 during S. pneumoniae lung infection and that Il22ra2 deficiency favors downregulation of oxidative phosphorylation (OXPHOS) genes in an IL-22-dependent manner. ...Transcriptome sequencing (RNA-seq) analysis of infected Il …
Here, we show that Il22ra2 inhibits IL-22 during S. pneumoniae lung infection and that Il22ra2 deficiency favors downregulatio …
Long Interleukin-22 Binding Protein Isoform-1 Is an Intracellular Activator of the Unfolded Protein Response.
Gómez-Fernández P, Urtasun A, Paton AW, Paton JC, Borrego F, Dersh D, Argon Y, Alloza I, Vandenbroeck K. Gómez-Fernández P, et al. Front Immunol. 2018 Dec 14;9:2934. doi: 10.3389/fimmu.2018.02934. eCollection 2018. Front Immunol. 2018. PMID: 30619294 Free PMC article.
The human IL22RA2 gene co-produces three protein isoforms in dendritic cells [IL-22 binding protein isoform-1 (IL-22BPi1), IL-22BPi2, and IL-22BPi3]. ...Upon silencing of IL22RA2 expression in moDC, GRP78 levels were significantly reduced, suggesting that native …
The human IL22RA2 gene co-produces three protein isoforms in dendritic cells [IL-22 binding protein isoform-1 (IL-22BPi1), IL-22BPi2, …
Regulation of IL-22BP in psoriasis.
Voglis S, Moos S, Kloos L, Wanke F, Zayoud M, Pelczar P, Giannou AD, Pezer S, Albers M, Luessi F, Huber S, Schäkel K, Kurschus FC. Voglis S, et al. Sci Rep. 2018 Mar 23;8(1):5085. doi: 10.1038/s41598-018-23510-3. Sci Rep. 2018. PMID: 29572462 Free PMC article.
95 results