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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1992 1
1996 1
1997 1
2000 1
2001 4
2002 10
2003 6
2004 8
2005 16
2006 27
2007 17
2008 19
2009 13
2010 21
2011 32
2012 40
2013 30
2014 45
2015 58
2016 39
2017 54
2018 45
2019 52
2020 71
2021 57
2022 41
2023 56
2024 15

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685 results

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Page 1
Lactobacillus plantarum-derived indole-3-lactic acid ameliorates colorectal tumorigenesis via epigenetic regulation of CD8+ T cell immunity.
Zhang Q, Zhao Q, Li T, Lu L, Wang F, Zhang H, Liu Z, Ma H, Zhu Q, Wang J, Zhang X, Pei Y, Liu Q, Xu Y, Qie J, Luan X, Hu Z, Liu X. Zhang Q, et al. Cell Metab. 2023 Jun 6;35(6):943-960.e9. doi: 10.1016/j.cmet.2023.04.015. Epub 2023 May 15. Cell Metab. 2023. PMID: 37192617
Mechanistically, we indicated that indole-3-lactic acid accelerated IL12a production in dendritic cells by enhancing H3K27ac binding at the enhancer regions of IL12a that contributed to priming CD8(+) T cell immunity against tumor growth. ...
Mechanistically, we indicated that indole-3-lactic acid accelerated IL12a production in dendritic cells by enhancing H3K27ac binding …
Il12a Deletion Aggravates Sepsis-Induced Cardiac Dysfunction by Regulating Macrophage Polarization.
Wang Z, Liu M, Ye D, Ye J, Wang M, Liu J, Xu Y, Zhang J, Zhao M, Feng Y, Xu S, Pan W, Luo Z, Li D, Wan J. Wang Z, et al. Front Pharmacol. 2021 Jul 2;12:632912. doi: 10.3389/fphar.2021.632912. eCollection 2021. Front Pharmacol. 2021. PMID: 34276358 Free PMC article.
In addition, Il12a knockout mice were used to detect the role of Il12a in sepsis-related cardiac dysfunction. We observed for the first time that Il12a expression is upregulated in mice after LPS treatment and macrophages were the main sources of Il12a …
In addition, Il12a knockout mice were used to detect the role of Il12a in sepsis-related cardiac dysfunction. We observed for …
MEF2C promotes M1 macrophage polarization and Th1 responses.
Zhao X, Di Q, Liu H, Quan J, Ling J, Zhao Z, Xiao Y, Wu H, Wu Z, Song W, An H, Chen W. Zhao X, et al. Cell Mol Immunol. 2022 Apr;19(4):540-553. doi: 10.1038/s41423-022-00841-w. Epub 2022 Feb 22. Cell Mol Immunol. 2022. PMID: 35194174 Free PMC article.
MEF2C significantly promoted the expression of interleukin-12 p35 subunit (Il12a) and interleukin-12 p40 subunit (Il12b). Myeloid-specific Mef2c-knockout mice showed reduced IL-12 production and impaired Th1 responses, which led to susceptibility to Listeria monocytogenes …
MEF2C significantly promoted the expression of interleukin-12 p35 subunit (Il12a) and interleukin-12 p40 subunit (Il12b). Myeloid-spe …
Masking the immunotoxicity of interleukin-12 by fusing it with a domain of its receptor via a tumour-protease-cleavable linker.
Mansurov A, Hosseinchi P, Chang K, Lauterbach AL, Gray LT, Alpar AT, Budina E, Slezak AJ, Kang S, Cao S, Solanki A, Gomes S, Williford JM, Swartz MA, Mendoza JL, Ishihara J, Hubbell JA. Mansurov A, et al. Nat Biomed Eng. 2022 Jul;6(7):819-829. doi: 10.1038/s41551-022-00888-0. Epub 2022 May 9. Nat Biomed Eng. 2022. PMID: 35534574
IL12A, MPHOSPH9/CDK2AP1 and RGS1 are novel multiple sclerosis susceptibility loci.
International Multiple Sclerosis Genetics Conssortium (IMSGC). International Multiple Sclerosis Genetics Conssortium (IMSGC). Genes Immun. 2010 Jul;11(5):397-405. doi: 10.1038/gene.2010.28. Epub 2010 Jun 17. Genes Immun. 2010. PMID: 20555355 Free PMC article.
Three loci exceeded genome-wide significance in the joint analysis: RGS1 (P value=3.55 x 10(-9)), IL12A (P=3.08 x 10(-8)) and MPHOSPH9/CDK2AP1 (P=3.96 x 10(-8)). The RGS1 risk allele is shared with celiac disease (CD), and the IL12A risk allele seems to be protectiv …
Three loci exceeded genome-wide significance in the joint analysis: RGS1 (P value=3.55 x 10(-9)), IL12A (P=3.08 x 10(-8)) and MPHOSPH …
SIRPα and PD1 expression on tumor-associated macrophage predict prognosis of intrahepatic cholangiocarcinoma.
Yang H, Yan M, Li W, Xu L. Yang H, et al. J Transl Med. 2022 Mar 22;20(1):140. doi: 10.1186/s12967-022-03342-6. J Transl Med. 2022. PMID: 35317832 Free PMC article.
We then examined some of M1 and M2 markers, and we found that M1 markers (iNOS, TNF, IL12A, and B) increased, while M2 markers (ARG1 and CD206) decreased in ICCs compared with paracancerous tissues. ...
We then examined some of M1 and M2 markers, and we found that M1 markers (iNOS, TNF, IL12A, and B) increased, while M2 markers (ARG1 …
Polymorphisms in IL12A and cockroach allergy in children with asthma.
Pistiner M, Hunninghake GM, Soto-Quiros ME, Avila L, Murphy A, Lasky-Su J, Schuemann B, Klanderman BJ, Raby BA, Celedón JC. Pistiner M, et al. Clin Mol Allergy. 2008 Jul 31;6:6. doi: 10.1186/1476-7961-6-6. Clin Mol Allergy. 2008. PMID: 18671862 Free PMC article.
BACKGROUND: IL12A has been implicated in T-cell development and may thus influence the development of atopy and allergic diseases. ...CONCLUSION: Our findings suggest that variants in IL12A influence cockroach allergy among children with asthma....
BACKGROUND: IL12A has been implicated in T-cell development and may thus influence the development of atopy and allergic diseases. .. …
Meta-Analysis on Associations of RGS1 and IL12A Polymorphisms with Celiac Disease Risk.
Guo CC, Wang M, Cao FD, Huang WH, Xiao D, Ye XG, Ou ML, Zhang N, Zhang BH, Liu Y, Yang G, Jing CX. Guo CC, et al. Int J Mol Sci. 2016 Mar 30;17(4):457. doi: 10.3390/ijms17040457. Int J Mol Sci. 2016. PMID: 27043536 Free PMC article.
The pathogenesis of celiac disease (CD) has been related to polymorphisms in the regulator of G-protein signaling 1 (RGS1) and interleukin-12 A (IL12A) genes, but the existing findings are inconsistent. Our aim is to investigate the associations of two single-nucleotide po …
The pathogenesis of celiac disease (CD) has been related to polymorphisms in the regulator of G-protein signaling 1 (RGS1) and interleukin-1 …
685 results