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Items: 1 to 20 of 151

1.

Cardioprotective Effects of VCP Modulator KUS121 in Murine and Porcine Models of Myocardial Infarction.

Ide Y, Horie T, Saito N, Watanabe S, Otani C, Miyasaka Y, Kuwabara Y, Nishino T, Nakao T, Nishiga M, Nishi H, Nakashima Y, Nakazeki F, Koyama S, Kimura M, Tsuji S, Rodriguez RR, Xu S, Yamasaki T, Watanabe T, Yamamoto M, Yanagita M, Kimura T, Kakizuka A, Ono K.

JACC Basic Transl Sci. 2019 Oct 28;4(6):701-714. doi: 10.1016/j.jacbts.2019.06.001. eCollection 2019 Oct.

2.

Crystal structure of the catalytic D2 domain of the AAA+ ATPase p97 reveals a putative helical split-washer-type mechanism for substrate unfolding.

Stach L, Morgan RM, Makhlouf L, Douangamath A, von Delft F, Zhang X, Freemont PS.

FEBS Lett. 2019 Nov 7. doi: 10.1002/1873-3468.13667. [Epub ahead of print]

PMID:
31701538
3.

Inclusion Body Myopathy with Paget Disease of Bone and/or Frontotemporal Dementia.

Kimonis V.

In: Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens K, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2019.
2007 May 25 [updated 2019 Sep 12].

4.

VCP/p97 controls signals of the ERK1/2 pathway transmitted via the Shoc2 scaffolding complex: novel insights into IBMPFD pathology.

Jang H, Jang ER, Wilson PG, Anderson D, Galperin E.

Mol Biol Cell. 2019 Jul 1;30(14):1655-1663. doi: 10.1091/mbc.E19-03-0144. Epub 2019 May 15.

5.
6.

VCP maintains lysosomal homeostasis and TFEB activity in differentiated skeletal muscle.

Arhzaouy K, Papadopoulos C, Schulze N, Pittman SK, Meyer H, Weihl CC.

Autophagy. 2019 Jun;15(6):1082-1099. doi: 10.1080/15548627.2019.1569933. Epub 2019 Jan 29.

PMID:
30654731
7.

Cooperative subunit dynamics modulate p97 function.

Huang R, Ripstein ZA, Rubinstein JL, Kay LE.

Proc Natl Acad Sci U S A. 2019 Jan 2;116(1):158-167. doi: 10.1073/pnas.1815495116. Epub 2018 Dec 24.

8.

The heterozygous R155C VCP mutation: Toxic in humans! Harmless in mice?

Clemen CS, Winter L, Strucksberg KH, Berwanger C, Türk M, Kornblum C, Florin A, Aguilar-Pimentel JA, Amarie OV, Becker L, Garrett L, Hans W, Moreth K, Neff F, Pingen L, Rathkolb B, Rácz I, Rozman J, Treise I, Fuchs H, Gailus-Durner V, de Angelis MH, Vorgerd M, Eichinger L, Schröder R.

Biochem Biophys Res Commun. 2018 Sep 18;503(4):2770-2777. doi: 10.1016/j.bbrc.2018.08.038. Epub 2018 Aug 9.

9.

A cross-sectional analysis of clinical evaluation in 35 individuals with mutations of the valosin-containing protein gene.

Plewa J, Surampalli A, Wencel M, Milad M, Donkervoort S, Caiozzo VJ, Goyal N, Mozaffar T, Kimonis V.

Neuromuscul Disord. 2018 Sep;28(9):778-786. doi: 10.1016/j.nmd.2018.06.007. Epub 2018 Jun 27.

10.

[Inclusion Body Myopathy, Paget's Disease, and Fronto-temporal Dementia: a VCP-related Multi-systemic Proteinopathy].

Mengel D, Librizzi D, Schoser B, Gläser D, Clemen CS, Dodel R, Schröder R.

Fortschr Neurol Psychiatr. 2018 Jul;86(7):434-438. doi: 10.1055/s-0044-101033. Epub 2018 Jul 20. German.

PMID:
30029282
11.

Loss of the novel Vcp (valosin containing protein) interactor Washc4 interferes with autophagy-mediated proteostasis in striated muscle and leads to myopathy in vivo.

Kustermann M, Manta L, Paone C, Kustermann J, Lausser L, Wiesner C, Eichinger L, Clemen CS, Schröder R, Kestler HA, Sandri M, Rottbauer W, Just S.

Autophagy. 2018;14(11):1911-1927. doi: 10.1080/15548627.2018.1491491. Epub 2018 Aug 16.

12.

Two novel VCP missense variants identified in Japanese patients with multisystem proteinopathy.

Inoue M, Iida A, Hayashi S, Mori-Yoshimura M, Nagaoka A, Yoshimura S, Shiraishi H, Tsujino A, Takahashi Y, Nonaka I, Hayashi YK, Noguchi S, Nishino I.

Hum Genome Var. 2018 May 30;5:9. doi: 10.1038/s41439-018-0009-7. eCollection 2018.

13.

ZFAND1 Recruits p97 and the 26S Proteasome to Promote the Clearance of Arsenite-Induced Stress Granules.

Turakhiya A, Meyer SR, Marincola G, Böhm S, Vanselow JT, Schlosser A, Hofmann K, Buchberger A.

Mol Cell. 2018 Jun 7;70(5):906-919.e7. doi: 10.1016/j.molcel.2018.04.021. Epub 2018 May 24.

14.

The multifaceted clinical presentation of VCP-proteinopathy in a Greek family.

Papadimas GK, Paraskevas GP, Zambelis T, Karagiaouris C, Bourbouli M, Bougea A, Walter MC, Schumacher NU, Krause S, Kapaki E.

Acta Myol. 2017 Dec 1;36(4):203-206. eCollection 2017 Dec.

15.
16.

Structural basis for nucleotide-modulated p97 association with the ER membrane.

Tang WK, Zhang T, Ye Y, Xia D.

Cell Discov. 2017 Dec 12;3:17045. doi: 10.1038/celldisc.2017.45. eCollection 2017.

17.

A Brazilian family with inclusion body myopathy associated with Paget's disease of bone and frontotemporal dementia linked to the VCP pGly97Glu mutation.

Shinjo SK, Oba-Shinjo SM, Lerario AM, Marie SKN.

Clin Rheumatol. 2018 Apr;37(4):1129-1136. doi: 10.1007/s10067-017-3913-1. Epub 2017 Nov 10. Review.

PMID:
29127544
18.

Roles for the VCP co-factors Npl4 and Ufd1 in neuronal function in Drosophila melanogaster.

Byrne DJ, Harmon MJ, Simpson JC, Blackstone C, O'Sullivan NC.

J Genet Genomics. 2017 Oct 20;44(10):493-501. doi: 10.1016/j.jgg.2017.06.003. Epub 2017 Sep 21.

19.

Valosin-containing protein (VCP) is a novel IQ motif-containing GTPase activating protein 1 (IQGAP1)-interacting protein.

Itoh N, Nagai T, Watanabe T, Taki K, Nabeshima T, Kaibuchi K, Yamada K.

Biochem Biophys Res Commun. 2017 Dec 2;493(4):1384-1389. doi: 10.1016/j.bbrc.2017.09.159. Epub 2017 Sep 29.

PMID:
28970065
20.

Exploiting conformational plasticity in the AAA+ protein VCP/p97 to modify function.

Schütz AK, Rennella E, Kay LE.

Proc Natl Acad Sci U S A. 2017 Aug 15;114(33):E6822-E6829. doi: 10.1073/pnas.1707974114. Epub 2017 Jul 31.

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