Format

Send to

Choose Destination
Bioinformation. 2010 Mar 31;4(9):430-5.

Analysis of casein alpha S1 & S2 proteins from different mammalian species.

Author information

1
Institute of Genetics and Hospital for Genetic Diseases, Begumpet, Hyderabad 500016, India. tahamasoodi@gmail.com

Abstract

Nowadays, the quality of any food used for human consumption is, to a considerable extent, considered by its possible contribution to the maintenance or improvement of the consumer's health. In developed countries there is increasing interest in goat milk and its derivates, the quality of which is considered of special importance in the light of current tendencies favouring healthy eating. In particular, goat's milk is a hypoallergenic alternative to cow's milk in the human diet. In the present work, we studied the casein alpha S1 and S2 proteins of cow, goat and sheep for comparative analysis. We found that the amino acid sequence of these proteins is almost same in goat and sheep but there are several changes at different base pairs when these two sequences are compared with cow. Prediction of secondary structures (GOR) was performed for alpha s1 and s2 proteins to gain functional insights. Our in silico study revealed considerable identity in chemical properties between goat and sheep but a considerable dissimilarity in cow with goat and sheep casein proteins. Moreover, the effect amino acid change on secondary structures in the three species is discussed. There was no significant difference found between goat and sheep alpha S1 and S2 proteins, so naturally both will be having same properties. The study concludes that sheep milk is another convenient alternative for the cow milk allergic children.

KEYWORDS:

alpha proteins; casein; sequence analysis

PMID:
20975894
PMCID:
PMC2951635

Supplemental Content

Full text links

Icon for PubMed Central
Loading ...
Support Center