Send to

Choose Destination

See 1 citation found by title matching your search:

Free Radic Res. 2018 Apr 23:1-12. doi: 10.1080/10715762.2018.1460749. [Epub ahead of print]

Hydrogen-rich water improves cognitive impairment gender-dependently in APP/PS1 mice without affectingclearance.

Hou C1,2, Peng Y1,2, Qin C1,2, Fan F1,2, Liu J1,2, Long J1,2.

Author information

a Center for Mitochondrial Biology and Medicine and Key Laboratory of Biomedical Information Engineering of the Ministry of Education , School of Life Science and Technology , Xi'an , China.
b Frontier Institute of Science and Technology , Xi'an Jiaotong University , Xi'an , China.


Alzheimer's disease (AD) is characterised as a provoked inflammatory response and oxidative stress along with amyloid β peptide (Aβ) deposition and neurofibrillary tangles in the brain, and effective treatment is greatly needed. Molecular hydrogen, which has been proposed to be an antioxidant that selectively reduces reactive oxygen species, was found to exert beneficial effects in Aβ injection-induced cognitive dysfunction. However, whether and how hydrogen affects AD pathogenesis remains uninvestigated. Thus, in the present study, APPswe/PS1dE9 (amyloid precursor protein (APP)/PS1) mice, a transgenic AD mouse model, were administered hydrogen-rich water for 3 months and the effects on cognitive function and molecular pathways were investigated. We found that hydrogen-rich water significantly improved cognitive behaviour in female transgenic AD mice without affectingclearance, and reversed the brain oestrogen level, ERβ, and brain-derived neurotrophic factor (BDNF) expressions that were damaged in female transgenic AD mice, but not in males. Furthermore, hydrogen-rich water ameliorated oxidative stress and inflammatory responses more profoundly in the brains of female AD mice than in those of males. Our results demonstrate a novel sex-specific beneficial effect of hydrogen via oestrogen and brain ERβ-BDNF signalling in AD pathogenesis.


Alzheimer’s disease; Molecular hydrogen; cognitive function; female; oestrogen

Supplemental Content

Full text links

Icon for Taylor & Francis
Loading ...
Support Center