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Clin Exp Hypertens. 2019;41(4):307-311. doi: 10.1080/10641963.2018.1481419. Epub 2018 Jun 14.

Hydrogen gas improves left ventricular hypertrophy in Dahl rat of salt-sensitive hypertension.

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a Department of Biomedical Sciences , Chubu University Graduate School of Life and Health Sciences , Kasugai , Japan.
b Department of Psychiatry , Nagoya University Graduate School of Medicine , Nagoya , Japan.
c Department of Pathophysiological Laboratory Sciences , Nagoya University Graduate School of Medicine , Nagoya , Japan.
d Center for Education in Laboratory Animal Research , Chubu University , Kasugai , Japan.



Hypertension is an important risk factor for death resulting from stroke, myocardial infarction, and end-stage renal failure. Hydrogen (H2) gas protects against many diseases, including ischemia-reperfusion injury and stroke. The effects of H2 on hypertension and its related left ventricular (LV) function have not been fully elucidated. The purpose of this study was to investigate the effects of H2 gas on hypertension and LV hypertrophy using echocardiography.


Dahl salt-sensitive (DS) rats were randomly divided into three groups: those fed an 8% NaCl diet until 12 weeks of age (8% NaCl group), those additionally treated with 2% H2 gas (8% NaCl + 2% H2 group), and control rats maintained on a diet containing 0.3% NaCl until 12 weeks of age (0.3% NaCl group). H2 gas was supplied through a gas flowmeter and delivered by room air (2% hydrogenated room air, flow rate of 10 L/min) into a cage surrounded by an acrylic chamber. We evaluated interventricular septal wall thickness (IVST), LV posterior wall thickness (LVPWT), and LV mass using echocardiography.


IVST, LVPWT, and LV mass were significantly higher in the 8% NaCl group than the 0.3% NaCl group at 12 weeks of age, whereas they were significantly lower in the 8% NaCl + 2% H2 group than the 8% NaCl group. There was no significant difference in systolic blood pressure between the two groups.


Our findings suggest that chronic H2 gas inhalation may help prevent LV hypertrophy in hypertensive DS rats.


Salt sensitive hypertension; antioxidant effect; cardiac hypertrophy; hydrogen gas; reactive oxygen species

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