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Antioxid Redox Signal. 2013 Apr 20;18(12):1463-74. doi: 10.1089/ars.2012.4734. Epub 2012 Aug 17.

Hydrogen peroxide as an immunological transmitter regulating autoreactive T cells.

Author information

1
Medical Inflammation Research, MBB, Karolinska Institutet, Stockholm, Sweden. Rikard.Holmdahl@ki.se

Abstract

SIGNIFICANCE:

An unexpected finding, revealed by positional cloning of genetic polymorphisms controlling models for rheumatoid arthritis, exposed a new function of Ncf1 and NADPH oxidase (NOX) 2 controlled oxidative burst.

RECENT ADVANCES:

A decreased capacity to produce ROS due to a natural polymorphism was found to be the major factor leading to more severe arthritis and increased T cell-dependent autoimmunity.

CRITICAL ISSUES:

In the vein of this finding, we here review a possible new role of ROS in regulating inflammatory cell and autoreactive T cell activity. It is postulated that peroxide is an immunologic transmitter secreted by antigen-presenting cells that downregulate the responses by autoreactive T cells.

FUTURE DIRECTIONS:

This may operate at different levels of T cell selection and activation: during negative selection in the thymus, priming of T cells in draining lymph nodes, and while interacting with macrophages in peripheral target tissues.

PMID:
22900704
DOI:
10.1089/ars.2012.4734
[Indexed for MEDLINE]

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