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Colloids Surf B Biointerfaces. 2017 Feb 1;150:297-307. doi: 10.1016/j.colsurfb.2016.10.042. Epub 2016 Oct 26.

Hybrid systems based on gold nanostructures and porphyrins as promising photosensitizers for photodynamic therapy.

Author information

1
Departamento de Física, Instituto de Ciências Exatas, Universidade Federal de Minas Gerais, Belo Horizonte-MG, 31270-901, Brazil. Electronic address: daniele.c.fer@gmail.com.
2
Departamento de Química, Instituto de Ciências Exatas, Universidade Federal de Minas Gerais, Belo Horizonte-MG, 31270-901, Brazil.
3
Departamento de Física, Instituto de Ciências Exatas, Universidade Federal de Minas Gerais, Belo Horizonte-MG, 31270-901, Brazil.

Abstract

Gold nanostructures of two different shapes (spheres and rods) were synthesized to form a colloidal hybrid system with 5,10,15,20-tetrakis(N-methylpyridinium-4-yl)porphyrin tosylate salt (H2TM4PyP(OTs)4) (POR) for applications in photodynamic therapy (PDT) using light in the visible spectral range. Electron paramagnetic resonance (EPR) experiments in combination with spin trapping were used for the detection of reactive oxygen species (ROS) and evaluation of the efficiency of these novel hybrid systems as photosensitizers. It is shown that the hybrid system consisting of gold nanorods (AuNR) and porphyrin (POR) is by far more efficient than its isolated components. This enhanced efficiency is explained by a synergetic effect between the AuNR and the porphyrin, wherein a rapid energy transfer from the former to the latter produces a large amount of singlet oxygen followed by its conversion into hydroxyl radicals. The mechanism was investigated using different spin traps and different ROS inhibitors. On the other hand, spherical gold nanoparticles (AuNP) do not show this synergetic effect. The synergetic effect for gold nanorods/POR hybrid is attributed to a larger field enhancement close to the gold nanorod surface in addition to the electrostatic attraction between the components of the hybrid system.

KEYWORDS:

Gold nanoparticles; Gold nanorods; Photodynamic therapy (PDT); Porphyrin; Reactive oxygen species (ROS)

PMID:
28029548
DOI:
10.1016/j.colsurfb.2016.10.042
[Indexed for MEDLINE]

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