Format

Send to

Choose Destination

See 1 citation found using an alternative search:

J Pediatr. 1998 Aug;133(2):201-5.

Growth hormone replacement and the risk of malignancy in children with neurofibromatosis.

Author information

1
Department of Endocrinology, Christie Hospital NHS Trust, Withington, Manchester, United Kingdom.

Abstract

OBJECTIVE:

To assess the efficacy and safety of growth hormone (GH) therapy in children with GH deficiency in association with neurofibromatosis.

METHODS:

Retrospective analysis of data from the Pharmacia and Upjohn International Growth Database (KIGS) in a total of 102 GH-deficient children with neurofibromatosis treated with recombinant GH.

RESULTS:

Median pretreatment height velocity was 4.2 cm/yr (1.7 to 6.4 cm/yr), increased to 7.1 cm/yr (4.6 to 10.0 cm/yr) in the first year of GH therapy, and remained significantly greater than pretreatment at 5.7 cm/yr (2.9 to 8.3 cm/yr) and 5.7 cm/yr (2.6 to 7.9 cm/yr) in the second and third years, respectively. The median height SD score increased from -2.4 to -1.8 by the end of 3 years of treatment. Five patients had either a recurrence of an intracranial tumor or a second intracranial tumor; this incidence of tumor occurrence is comparable to that reported previously in similar patients with neurofibromatosis. Other adverse events were relatively minor and unlikely to be attributable to GH therapy

CONCLUSIONS:

The data indicate that GH replacement therapy, per se, for patients with neurofibromatosis and GH deficiency is likely to be beneficial and unassociated with excessive malignant risk.

PMID:
9709706
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center