How to validate a heteromeric ion channel drug target: assessing proper expression of concatenated subunits

J Gen Physiol. 2008 May;131(5):415-20. doi: 10.1085/jgp.200709939. Epub 2008 Apr 14.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biomarkers, Pharmacological
  • Drug Design
  • Gene Expression
  • Humans
  • Ion Channels / drug effects*
  • Ion Channels / genetics*
  • Pharmaceutical Preparations / administration & dosage
  • Protein Engineering / trends
  • Protein Subunits / genetics*

Substances

  • Biomarkers, Pharmacological
  • Ion Channels
  • Pharmaceutical Preparations
  • Protein Subunits