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The authors reply.

Hotchkiss RS, Yende S, Angus DC, Moldawer LL, Crouser E, Martin G, Coopersmith CM, Brakenridge S, Mayr FB, Park PK.

Crit Care Med. 2019 Sep;47(9):e788-e789. doi: 10.1097/CCM.0000000000003887. No abstract available.


The Association of Fever and Antipyretic Medication With Outcomes in Mechanically Ventilated Patients: A Cohort Study.

Evans EM, Doctor RJ, Gage BF, Hotchkiss RS, Fuller BM, Drewry AM.

Shock. 2019 Aug;52(2):152-159. doi: 10.1097/SHK.0000000000001368.


What Is the Skinny on Obesity During Sepsis?

Crouser ED, Caldwell CC, Hotchkiss RS.

Crit Care Med. 2019 May;47(5):735-736. doi: 10.1097/CCM.0000000000003707. No abstract available.


An Aspirin a Day Keeps the Intensivist Away?

Turnbull IR, Hotchkiss RS.

Crit Care Med. 2019 Apr;47(4):603-604. doi: 10.1097/CCM.0000000000003672. No abstract available.


Immune Checkpoint Inhibition in Sepsis: A Phase 1b Randomized, Placebo-Controlled, Single Ascending Dose Study of Antiprogrammed Cell Death-Ligand 1 Antibody (BMS-936559).

Hotchkiss RS, Colston E, Yende S, Angus DC, Moldawer LL, Crouser ED, Martin GS, Coopersmith CM, Brakenridge S, Mayr FB, Park PK, Ye J, Catlett IM, Girgis IG, Grasela DM.

Crit Care Med. 2019 May;47(5):632-642. doi: 10.1097/CCM.0000000000003685.


Immunoadjuvant therapy in sepsis: novel strategies for immunosuppressive sepsis coming down the pike.

Watanabe E, Thampy LK, Hotchkiss RS.

Acute Med Surg. 2018 Aug 6;5(4):309-315. doi: 10.1002/ams2.363. eCollection 2018 Oct.


Restoration of T Cell function in multi-drug resistant bacterial sepsis after interleukin-7, anti-PD-L1, and OX-40 administration.

Thampy LK, Remy KE, Walton AH, Hong Z, Liu K, Liu R, Yi V, Burnham CD, Hotchkiss RS.

PLoS One. 2018 Jun 26;13(6):e0199497. doi: 10.1371/journal.pone.0199497. eCollection 2018.


Interleukin-7 restores lymphocytes in septic shock: the IRIS-7 randomized clinical trial.

Francois B, Jeannet R, Daix T, Walton AH, Shotwell MS, Unsinger J, Monneret G, Rimmelé T, Blood T, Morre M, Gregoire A, Mayo GA, Blood J, Durum SK, Sherwood ER, Hotchkiss RS.

JCI Insight. 2018 Mar 8;3(5). pii: 98960. doi: 10.1172/jci.insight.98960.


Monocyte Function and Clinical Outcomes in Febrile and Afebrile Patients With Severe Sepsis.

Drewry AM, Ablordeppey EA, Murray ET, Dalton CM, Fuller BM, Kollef MH, Hotchkiss RS.

Shock. 2018 Oct;50(4):381-387. doi: 10.1097/SHK.0000000000001083.


Host-directed therapies for bacterial and viral infections.

Kaufmann SHE, Dorhoi A, Hotchkiss RS, Bartenschlager R.

Nat Rev Drug Discov. 2018 Jan;17(1):35-56. doi: 10.1038/nrd.2017.162. Epub 2017 Sep 22. Review.


Deep Immune Profiling in Trauma and Sepsis: Flow Is the Way to Go!

Gaudilliere B, Angst MS, Hotchkiss RS.

Crit Care Med. 2017 Sep;45(9):1577-1578. doi: 10.1097/CCM.0000000000002594. No abstract available.


Lung-Protective Ventilation Initiated in the Emergency Department (LOV-ED): A Quasi-Experimental, Before-After Trial.

Fuller BM, Ferguson IT, Mohr NM, Drewry AM, Palmer C, Wessman BT, Ablordeppey E, Keeperman J, Stephens RJ, Briscoe CC, Kolomiets AA, Hotchkiss RS, Kollef MH.

Ann Emerg Med. 2017 Sep;70(3):406-418.e4. doi: 10.1016/j.annemergmed.2017.01.013. Epub 2017 Mar 2.


A Quasi-Experimental, Before-After Trial Examining the Impact of an Emergency Department Mechanical Ventilator Protocol on Clinical Outcomes and Lung-Protective Ventilation in Acute Respiratory Distress Syndrome.

Fuller BM, Ferguson IT, Mohr NM, Drewry AM, Palmer C, Wessman BT, Ablordeppey E, Keeperman J, Stephens RJ, Briscoe CC, Kolomiets AA, Hotchkiss RS, Kollef MH.

Crit Care Med. 2017 Apr;45(4):645-652. doi: 10.1097/CCM.0000000000002268.


Sepsis and septic shock.

Hotchkiss RS, Moldawer LL, Opal SM, Reinhart K, Turnbull IR, Vincent JL.

Nat Rev Dis Primers. 2016 Jun 30;2:16045. doi: 10.1038/nrdp.2016.45. Review.


Widespread Down-Regulation of Cardiac Mitochondrial and Sarcomeric Genes in Patients With Sepsis.

Matkovich SJ, Al Khiami B, Efimov IR, Evans S, Vader J, Jain A, Brownstein BH, Hotchkiss RS, Mann DL.

Crit Care Med. 2017 Mar;45(3):407-414. doi: 10.1097/CCM.0000000000002207.


Nivolumab plus interferon-γ in the treatment of intractable mucormycosis.

Grimaldi D, Pradier O, Hotchkiss RS, Vincent JL.

Lancet Infect Dis. 2017 Jan;17(1):18. doi: 10.1016/S1473-3099(16)30541-2. No abstract available.


Anti-PD-L1 peptide improves survival in sepsis.

Shindo Y, McDonough JS, Chang KC, Ramachandra M, Sasikumar PG, Hotchkiss RS.

J Surg Res. 2017 Feb;208:33-39. doi: 10.1016/j.jss.2016.08.099. Epub 2016 Sep 8.


Desperate Times Call for Desperate Measures: Self-Cannibalism Is Protective During Sepsis.

Crouser ED, Hotchkiss RS.

Crit Care Med. 2017 Jan;45(1):145-147. No abstract available.


Sepsis: Preventing organ failure in sepsis - the search continues.

Graetz TJ, Hotchkiss RS.

Nat Rev Nephrol. 2017 Jan;13(1):5-6. doi: 10.1038/nrneph.2016.171. Epub 2016 Nov 21. No abstract available.


Comparison of monocyte human leukocyte antigen-DR expression and stimulated tumor necrosis factor alpha production as outcome predictors in severe sepsis: a prospective observational study.

Drewry AM, Ablordeppey EA, Murray ET, Beiter ER, Walton AH, Hall MW, Hotchkiss RS.

Crit Care. 2016 Oct 20;20(1):334. doi: 10.1186/s13054-016-1505-0.

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