Format

Send to

Choose Destination

See 1 citation found by title matching your search:

Nat Commun. 2014 Jul 25;5:4446. doi: 10.1038/ncomms5446.

Host iron status and iron supplementation mediate susceptibility to erythrocytic stage Plasmodium falciparum.

Author information

1
Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
2
1] Medical Research Council International Nutrition Group, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK [2] Medical Research Council, Keneba, The Gambia.
3
Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
4
Division of Infectious Diseases and International Health, Duke University Medical Center, Durham, North Carolina 27710, USA.
5
Division of Hematology Oncology, Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA.

Abstract

Iron deficiency and malaria have similar global distributions, and frequently co-exist in pregnant women and young children. Where both conditions are prevalent, iron supplementation is complicated by observations that iron deficiency anaemia protects against falciparum malaria, and that iron supplements increase susceptibility to clinically significant malaria, but the mechanisms remain obscure. Here, using an in vitro parasite culture system with erythrocytes from iron-deficient and replete human donors, we demonstrate that Plasmodium falciparum infects iron-deficient erythrocytes less efficiently. In addition, owing to merozoite preference for young erythrocytes, iron supplementation of iron-deficient individuals reverses the protective effects of iron deficiency. Our results provide experimental validation of field observations reporting protective effects of iron deficiency and harmful effects of iron administration on human malaria susceptibility. Because recovery from anaemia requires transient reticulocytosis, our findings imply that in malarious regions iron supplementation should be accompanied by effective measures to prevent falciparum malaria.

PMID:
25059846
PMCID:
PMC4249681
DOI:
10.1038/ncomms5446
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center