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Items: 1 to 20 of 72

1.

Thyrocyte-specific deletion of insulin and IGF-1 receptors induces papillary thyroid carcinoma-like lesions through EGFR pathway activation.

Ock S, Ahn J, Lee SH, Kim HM, Kang H, Kim YK, Kook H, Park WJ, Kim S, Kimura S, Jung CK, Shong M, Holzenberger M, Abel ED, Lee TJ, Cho BY, Kim HS, Kim J.

Int J Cancer. 2018 Nov 15;143(10):2458-2469. doi: 10.1002/ijc.31779. Epub 2018 Sep 22.

PMID:
30070361
2.

CaMKIIα Expression Defines Two Functionally Distinct Populations of Granule Cells Involved in Different Types of Odor Behavior.

Malvaut S, Gribaudo S, Hardy D, David LS, Daroles L, Labrecque S, Lebel-Cormier MA, Chaker Z, Coté D, De Koninck P, Holzenberger M, Trembleau A, Caille I, Saghatelyan A.

Curr Biol. 2017 Nov 6;27(21):3315-3329.e6. doi: 10.1016/j.cub.2017.09.058. Epub 2017 Oct 26.

3.

Disrupting IGF Signaling in Adult Mice Conditions Leanness, Resilient Energy Metabolism, and High Growth Hormone Pulses.

François JC, Aïd S, Chaker Z, Lacube P, Xu J, Fayad R, Côté F, Even P, Holzenberger M.

Endocrinology. 2017 Jul 1;158(7):2269-2283. doi: 10.1210/en.2017-00261.

PMID:
28881863
4.

Insulin-like growth factor 1 receptor regulates hypothermia during calorie restriction.

Cintron-Colon R, Sanchez-Alavez M, Nguyen W, Mori S, Gonzalez-Rivera R, Lien T, Bartfai T, Aïd S, François JC, Holzenberger M, Conti B.

Proc Natl Acad Sci U S A. 2017 Sep 5;114(36):9731-9736. doi: 10.1073/pnas.1617876114. Epub 2017 Aug 21.

5.

The Alzheimer's disease transcriptome mimics the neuroprotective signature of IGF-1 receptor-deficient neurons.

George C, Gontier G, Lacube P, François JC, Holzenberger M, Aïd S.

Brain. 2017 Jul 1;140(7):2012-2027. doi: 10.1093/brain/awx132.

PMID:
28595357
6.

Igf1r signalling acts on the anagen-to-catagen transition in the hair cycle.

Castela M, Linay F, Roy E, Moguelet P, Xu J, Holzenberger M, Khosrotehrani K, Aractingi S.

Exp Dermatol. 2017 Sep;26(9):785-791. doi: 10.1111/exd.13287. Epub 2017 Apr 27.

PMID:
28094870
7.

Hypothalamic neurogenesis persists in the aging brain and is controlled by energy-sensing IGF-I pathway.

Chaker Z, George C, Petrovska M, Caron JB, Lacube P, Caillé I, Holzenberger M.

Neurobiol Aging. 2016 May;41:64-72. doi: 10.1016/j.neurobiolaging.2016.02.008. Epub 2016 Feb 17.

PMID:
27103519
8.

Regulatory T cells delay disease progression in Alzheimer-like pathology.

Dansokho C, Ait Ahmed D, Aid S, Toly-Ndour C, Chaigneau T, Calle V, Cagnard N, Holzenberger M, Piaggio E, Aucouturier P, Dorothée G.

Brain. 2016 Apr;139(Pt 4):1237-51. doi: 10.1093/brain/awv408. Epub 2016 Feb 1.

PMID:
26912648
9.

Deleting IGF-1 receptor from forebrain neurons confers neuroprotection during stroke and upregulates endocrine somatotropin.

De Magalhaes Filho CD, Kappeler L, Dupont J, Solinc J, Villapol S, Denis C, Nosten-Bertrand M, Billard JM, Blaise A, Tronche F, Giros B, Charriaut-Marlangue C, Aïd S, Le Bouc Y, Holzenberger M.

J Cereb Blood Flow Metab. 2017 Feb;37(2):396-412. doi: 10.1177/0271678X15626718. Epub 2016 Jul 20.

10.

IGF-1R Reduction Triggers Neuroprotective Signaling Pathways in Spinal Muscular Atrophy Mice.

Biondi O, Branchu J, Ben Salah A, Houdebine L, Bertin L, Chali F, Desseille C, Weill L, Sanchez G, Lancelin C, Aïd S, Lopes P, Pariset C, Lécolle S, Côté J, Holzenberger M, Chanoine C, Massaad C, Charbonnier F.

J Neurosci. 2015 Aug 26;35(34):12063-79. doi: 10.1523/JNEUROSCI.0608-15.2015.

11.

Blocking IGF Signaling in Adult Neurons Alleviates Alzheimer's Disease Pathology through Amyloid-β Clearance.

Gontier G, George C, Chaker Z, Holzenberger M, Aïd S.

J Neurosci. 2015 Aug 19;35(33):11500-13. doi: 10.1523/JNEUROSCI.0343-15.2015.

12.

Suppression of IGF-I signals in neural stem cells enhances neurogenesis and olfactory function during aging.

Chaker Z, Aïd S, Berry H, Holzenberger M.

Aging Cell. 2015 Oct;14(5):847-56. doi: 10.1111/acel.12365. Epub 2015 Jul 29.

13.

Expression of dominant-negative thyroid hormone receptor alpha1 in Leydig and Sertoli cells demonstrates no additional defect compared with expression in Sertoli cells only.

Fumel B, Froment P, Holzenberger M, Livera G, Monget P, Fouchécourt S.

PLoS One. 2015 Mar 20;10(3):e0119392. doi: 10.1371/journal.pone.0119392. eCollection 2015.

14.

IGF-IR determines the fates of BCR/ABL leukemia.

Xie J, Chen X, Zheng J, Li C, Stacy S, Holzenberger M, Hu X, Zhang CC.

J Hematol Oncol. 2015 Feb 4;8:3. doi: 10.1186/s13045-015-0106-8.

15.

The intestinal epithelial insulin-like growth factor-1 receptor links glucagon-like peptide-2 action to gut barrier function.

Dong CX, Zhao W, Solomon C, Rowland KJ, Ackerley C, Robine S, Holzenberger M, Gonska T, Brubaker PL.

Endocrinology. 2014 Feb;155(2):370-9. doi: 10.1210/en.2013-1871. Epub 2013 Nov 21.

PMID:
24265452
16.

Longevity effect of IGF-1R(+/-) mutation depends on genetic background-specific receptor activation.

Xu J, Gontier G, Chaker Z, Lacube P, Dupont J, Holzenberger M.

Aging Cell. 2014 Feb;13(1):19-28. doi: 10.1111/acel.12145. Epub 2013 Sep 11.

17.

Knockout of insulin-like growth factor-1 receptor impairs distal lung morphogenesis.

Epaud R, Aubey F, Xu J, Chaker Z, Clemessy M, Dautin A, Ahamed K, Bonora M, Hoyeau N, Fléjou JF, Mailleux A, Clement A, Henrion-Caude A, Holzenberger M.

PLoS One. 2012;7(11):e48071. doi: 10.1371/journal.pone.0048071. Epub 2012 Nov 6.

18.

IGF signaling contributes to malignant transformation of hematopoietic progenitors by the MLL-AF9 oncoprotein.

Jenkins CR, Shevchuk OO, Giambra V, Lam SH, Carboni JM, Gottardis MM, Holzenberger M, Pollak M, Humphries RK, Weng AP.

Exp Hematol. 2012 Sep;40(9):715-723.e6. doi: 10.1016/j.exphem.2012.05.003. Epub 2012 May 18.

PMID:
22613471
19.

Proinflammatory actions of visfatin/nicotinamide phosphoribosyltransferase (Nampt) involve regulation of insulin signaling pathway and Nampt enzymatic activity.

Jacques C, Holzenberger M, Mladenovic Z, Salvat C, Pecchi E, Berenbaum F, Gosset M.

J Biol Chem. 2012 Apr 27;287(18):15100-8. doi: 10.1074/jbc.M112.350215. Epub 2012 Mar 7.

20.

Igf-I signaling and effects on longevity.

Holzenberger M.

Nestle Nutr Workshop Ser Pediatr Program. 2011;68:237-45; discussion 246-9. doi: 10.1159/000325914. Epub 2011 Oct 3. Review.

PMID:
22044904

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