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Items: 1 to 20 of 130

1.

Transcription Factors Drive Tet2-Mediated Enhancer Demethylation to Reprogram Cell Fate.

Sardina JL, Collombet S, Tian TV, Gómez A, Di Stefano B, Berenguer C, Brumbaugh J, Stadhouders R, Segura-Morales C, Gut M, Gut IG, Heath S, Aranda S, Di Croce L, Hochedlinger K, Thieffry D, Graf T.

Cell Stem Cell. 2018 Nov 1;23(5):727-741.e9. doi: 10.1016/j.stem.2018.08.016. Epub 2018 Sep 13.

PMID:
30220521
2.

Reduced MEK inhibition preserves genomic stability in naive human embryonic stem cells.

Di Stefano B, Ueda M, Sabri S, Brumbaugh J, Huebner AJ, Sahakyan A, Clement K, Clowers KJ, Erickson AR, Shioda K, Gygi SP, Gu H, Shioda T, Meissner A, Takashima Y, Plath K, Hochedlinger K.

Nat Methods. 2018 Sep;15(9):732-740. doi: 10.1038/s41592-018-0104-1. Epub 2018 Aug 20.

PMID:
30127506
3.

Prospective Isolation of Poised iPSC Intermediates Reveals Principles of Cellular Reprogramming.

Schwarz BA, Cetinbas M, Clement K, Walsh RM, Cheloufi S, Gu H, Langkabel J, Kamiya A, Schorle H, Meissner A, Sadreyev RI, Hochedlinger K.

Cell Stem Cell. 2018 Aug 2;23(2):289-305.e5. doi: 10.1016/j.stem.2018.06.013. Epub 2018 Jul 12.

PMID:
30017590
4.

An Intermediate Pluripotent State Controlled by MicroRNAs Is Required for the Naive-to-Primed Stem Cell Transition.

Du P, Pirouz M, Choi J, Huebner AJ, Clement K, Meissner A, Hochedlinger K, Gregory RI.

Cell Stem Cell. 2018 Jun 1;22(6):851-864.e5. doi: 10.1016/j.stem.2018.04.021. Epub 2018 May 24.

PMID:
29804889
5.

Direct Reprogramming of Mouse Fibroblasts into Functional Skeletal Muscle Progenitors.

Bar-Nur O, Gerli MFM, Di Stefano B, Almada AE, Galvin A, Coffey A, Huebner AJ, Feige P, Verheul C, Cheung P, Payzin-Dogru D, Paisant S, Anselmo A, Sadreyev RI, Ott HC, Tajbakhsh S, Rudnicki MA, Wagers AJ, Hochedlinger K.

Stem Cell Reports. 2018 May 8;10(5):1505-1521. doi: 10.1016/j.stemcr.2018.04.009.

6.

Nudt21 Controls Cell Fate by Connecting Alternative Polyadenylation to Chromatin Signaling.

Brumbaugh J, Di Stefano B, Wang X, Borkent M, Forouzmand E, Clowers KJ, Ji F, Schwarz BA, Kalocsay M, Elledge SJ, Chen Y, Sadreyev RI, Gygi SP, Hu G, Shi Y, Hochedlinger K.

Cell. 2018 Jan 25;172(3):629-631. doi: 10.1016/j.cell.2017.12.035. No abstract available.

7.

Nudt21 Controls Cell Fate by Connecting Alternative Polyadenylation to Chromatin Signaling.

Brumbaugh J, Di Stefano B, Wang X, Borkent M, Forouzmand E, Clowers KJ, Ji F, Schwarz BA, Kalocsay M, Elledge SJ, Chen Y, Sadreyev RI, Gygi SP, Hu G, Shi Y, Hochedlinger K.

Cell. 2018 Jan 11;172(1-2):106-120.e21. doi: 10.1016/j.cell.2017.11.023. Epub 2017 Dec 14. Erratum in: Cell. 2018 Jan 25;172(3):629-631.

PMID:
29249356
8.

Prolonged Mek1/2 suppression impairs the developmental potential of embryonic stem cells.

Choi J, Huebner AJ, Clement K, Walsh RM, Savol A, Lin K, Gu H, Di Stefano B, Brumbaugh J, Kim SY, Sharif J, Rose CM, Mohammad A, Odajima J, Charron J, Shioda T, Gnirke A, Gygi S, Koseki H, Sadreyev RI, Xiao A, Meissner A, Hochedlinger K.

Nature. 2017 Aug 10;548(7666):219-223. doi: 10.1038/nature23274. Epub 2017 Jul 26.

9.

Emerging roles of the histone chaperone CAF-1 in cellular plasticity.

Cheloufi S, Hochedlinger K.

Curr Opin Genet Dev. 2017 Oct;46:83-94. doi: 10.1016/j.gde.2017.06.004. Epub 2017 Jul 7. Review.

10.

Epigenetically Aberrant Stroma in MDS Propagates Disease via Wnt/β-Catenin Activation.

Bhagat TD, Chen S, Bartenstein M, Barlowe AT, Von Ahrens D, Choudhary GS, Tivnan P, Amin E, Marcondes AM, Sanders MA, Hoogenboezem RM, Kambhampati S, Ramachandra N, Mantzaris I, Sukrithan V, Laurence R, Lopez R, Bhagat P, Giricz O, Sohal D, Wickrema A, Yeung C, Gritsman K, Aplan P, Hochedlinger K, Yu Y, Pradhan K, Zhang J, Greally JM, Mukherjee S, Pellagatti A, Boultwood J, Will B, Steidl U, Raaijmakers MHGP, Deeg HJ, Kharas MG, Verma A.

Cancer Res. 2017 Sep 15;77(18):4846-4857. doi: 10.1158/0008-5472.CAN-17-0282. Epub 2017 Jul 6.

11.

Phf8 loss confers resistance to depression-like and anxiety-like behaviors in mice.

Walsh RM, Shen EY, Bagot RC, Anselmo A, Jiang Y, Javidfar B, Wojtkiewicz GJ, Cloutier J, Chen JW, Sadreyev R, Nestler EJ, Akbarian S, Hochedlinger K.

Nat Commun. 2017 May 9;8:15142. doi: 10.1038/ncomms15142.

12.

DUSP9 Modulates DNA Hypomethylation in Female Mouse Pluripotent Stem Cells.

Choi J, Clement K, Huebner AJ, Webster J, Rose CM, Brumbaugh J, Walsh RM, Lee S, Savol A, Etchegaray JP, Gu H, Boyle P, Elling U, Mostoslavsky R, Sadreyev R, Park PJ, Gygi SP, Meissner A, Hochedlinger K.

Cell Stem Cell. 2017 May 4;20(5):706-719.e7. doi: 10.1016/j.stem.2017.03.002. Epub 2017 Mar 30.

13.

Probabilistic Modeling of Reprogramming to Induced Pluripotent Stem Cells.

Liu LL, Brumbaugh J, Bar-Nur O, Smith Z, Stadtfeld M, Meissner A, Hochedlinger K, Michor F.

Cell Rep. 2016 Dec 20;17(12):3395-3406. doi: 10.1016/j.celrep.2016.11.080.

14.

Sox2 Suppresses Gastric Tumorigenesis in Mice.

Sarkar A, Huebner AJ, Sulahian R, Anselmo A, Xu X, Flattery K, Desai N, Sebastian C, Yram MA, Arnold K, Rivera M, Mostoslavsky R, Bronson R, Bass AJ, Sadreyev R, Shivdasani RA, Hochedlinger K.

Cell Rep. 2016 Aug 16;16(7):1929-41. doi: 10.1016/j.celrep.2016.07.034. Epub 2016 Aug 4.

15.

Erasure of DNA methylation, genomic imprints, and epimutations in a primordial germ-cell model derived from mouse pluripotent stem cells.

Miyoshi N, Stel JM, Shioda K, Qu N, Odajima J, Mitsunaga S, Zhang X, Nagano M, Hochedlinger K, Isselbacher KJ, Shioda T.

Proc Natl Acad Sci U S A. 2016 Aug 23;113(34):9545-50. doi: 10.1073/pnas.1610259113. Epub 2016 Aug 2. Erratum in: Proc Natl Acad Sci U S A. 2016 Sep 20;113(38):E5697. Odahima, Junko [corrected to Odajima, Junko].

16.

α-Ketoglutarate Accelerates the Initial Differentiation of Primed Human Pluripotent Stem Cells.

TeSlaa T, Chaikovsky AC, Lipchina I, Escobar SL, Hochedlinger K, Huang J, Graeber TG, Braas D, Teitell MA.

Cell Metab. 2016 Sep 13;24(3):485-493. doi: 10.1016/j.cmet.2016.07.002. Epub 2016 Jul 28.

17.

Cell reprogramming: Brain versus brawn.

Di Stefano B, Hochedlinger K.

Nature. 2016 Jun 16;534(7607):332-3. doi: 10.1038/nature18444. Epub 2016 Jun 8. No abstract available.

PMID:
27281201
18.

Local Genome Topology Can Exhibit an Incompletely Rewired 3D-Folding State during Somatic Cell Reprogramming.

Beagan JA, Gilgenast TG, Kim J, Plona Z, Norton HK, Hu G, Hsu SC, Shields EJ, Lyu X, Apostolou E, Hochedlinger K, Corces VG, Dekker J, Phillips-Cremins JE.

Cell Stem Cell. 2016 May 5;18(5):611-24. doi: 10.1016/j.stem.2016.04.004.

19.

A Serial shRNA Screen for Roadblocks to Reprogramming Identifies the Protein Modifier SUMO2.

Borkent M, Bennett BD, Lackford B, Bar-Nur O, Brumbaugh J, Wang L, Du Y, Fargo DC, Apostolou E, Cheloufi S, Maherali N, Elledge SJ, Hu G, Hochedlinger K.

Stem Cell Reports. 2016 May 10;6(5):704-716. doi: 10.1016/j.stemcr.2016.02.004. Epub 2016 Mar 3.

20.

Corrigendum: Hallmarks of pluripotency.

De Los Angeles A, Ferrari F, Xi R, Fujiwara Y, Benvenisty N, Deng H, Hochedlinger K, Jaenisch R, Lee S, Leitch HG, Lensch MW, Lujan E, Pei D, Rossant J, Wernig M, Park PJ, Daley GQ.

Nature. 2016 Mar 17;531(7594):400. doi: 10.1038/nature16470. Epub 2015 Dec 16. No abstract available.

PMID:
26675727

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