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Curr Opin Neurobiol. 2017 Apr;43:187-197. doi: 10.1016/j.conb.2017.04.005. Epub 2017 May 3.

Hippocampal function in rodents.

Author information

1
Neuroscience Institute, New York University School of Medicine, USA; Medical Scientist Training Program, New York University School of Medicine, USA.
2
Neuroscience Institute, New York University School of Medicine, USA; Department of Neuroscience and Physiology, New York University School of Medicine, USA. Electronic address: jayeeta.basu@nyumc.org.

Abstract

The hippocampus is crucial for the formation and recall of long-term memories about people, places, objects, and events. Capitalizing on high-resolution microscopy, in vivo electrophysiology, and genetic manipulation, recent research in rodents provides evidence for hippocampal ensemble coding on the spatial, episodic, and contextual dimensions. Here we highlight the functional contribution of newly described long-range connections between hippocampus and cortical areas, and the relative impact of inhibitory and excitatory dynamics in generating behaviorally relevant population activity. Our goal is to provide an integrated view of hippocampal circuit function to understand mnemonic computations at the systems and cellular levels that underlie adaptive learned behaviors.

PMID:
28477511
PMCID:
PMC5690575
DOI:
10.1016/j.conb.2017.04.005
[Indexed for MEDLINE]
Free PMC Article

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