Format

Send to

Choose Destination
FEBS Lett. 2012 Jul 4;586(14):1860-70. doi: 10.1016/j.febslet.2012.05.028. Epub 2012 May 28.

Structural studies of the TGF-βs and their receptors - insights into evolution of the TGF-β superfamily.

Author information

1
Department of Biochemistry, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA. hinck@uthscsa.edu

Abstract

TGF-βs are small secreted signaling proteins that function as vital regulators of cellular growth and differentiation. They signal through a single pair of receptors, known as TβR-I and TβR-II, and are among the most recently evolved members of the signaling superfamily to which they belong. This review provides an overview of the TGF-β, BMP, and activin receptor complexes that have been determined over the past several years. These structures underscore the shared ancestry of the TGF-βs with the BMPs and activins, but also provide insight as to how the TGF-βs diverged from the BMPs and activins to bind and assemble their receptors in a distinct manner. These distinctive modes of receptor binding engender the TGF-βs with high specificity for their receptors and allow them to fulfill their essential functions in vivo without interference from the many other proteins of the superfamily.

PMID:
22651914
DOI:
10.1016/j.febslet.2012.05.028
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center