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Adv Mater. 2016 Jan 6;28(1):40-9. doi: 10.1002/adma.201503255. Epub 2015 Nov 9.

Highly Elastic and Conductive Human-Based Protein Hybrid Hydrogels.

Author information

1
Biomaterials Innovation Research Center, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA.
2
Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
3
Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, 02115, USA.
4
Department of Chemical Engineering, Northeastern University, Boston, MA, 02115-5000, USA.
5
Department of Cardiovascular Surgery, Heinrich Heine University, 40225, Düsseldorf, Germany.
6
Department of Material Science and Engineering, Seoul National University, Seoul, 151-742, South Korea.
7
Molecular Bioscience, Charles Perkins Centre, Bosch Institute, University of Sydney, Sydney, NSW, 2006, Australia.
8
Department of Chemistry, University of Waterloo, Waterloo, Ontario, N2L 3G1, Canada.
9
Department of Physics, King Abdulaziz University, Jeddah, 21569, Saudi Arabia.

Abstract

A highly elastic hybrid hydrogel of methacryloyl-substituted recombinant human tropoelastin (MeTro) and graphene oxide (GO) nanoparticles are developed. The synergistic effect of these two materials significantly enhances both ultimate strain (250%), reversible rotation (9700°), and the fracture energy (38.8 ± 0.8 J m(-2) ) in the hybrid network. Furthermore, improved electrical signal propagation and subsequent contraction of the muscles connected by hybrid hydrogels are observed in ex vivo tests.

KEYWORDS:

cardiac tissue engineering; elasticity; graphene oxides; hydrogels; tropoelastins

PMID:
26551969
PMCID:
PMC4863466
DOI:
10.1002/adma.201503255
[Indexed for MEDLINE]
Free PMC Article

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