Send to

Choose Destination

See 1 citation found by title matching your search:

BMJ Open. 2017 May 2;7(4):e014345. doi: 10.1136/bmjopen-2016-014345.

High adherence to the 'Wise List' treatment recommendations in Stockholm: a 15-year retrospective review of a multifaceted approach promoting rational use of medicines.

Author information

Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.
Department of Clinical Pharmacology, Karolinska University Hospital, Stockholm, Sweden.
Stockholm Drug and Therapeutics Committee, Public Healthcare Services Committee, Stockholm, Sweden.
Medical Management Centre, Department of Learning, Informatics, Management and Ethics (LIME), Karolinska Institutet, Stockholm, Sweden.
Department of Quality and Development, Södersjukhuset, Stockholm, Sweden.
Public Healthcare Services Committee, Stockholm, Sweden.
Department of Clinical Science and Education, Södersjukhuset, Internal Medicine, Karolinska Institutet, Stockholm, Sweden.
Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.



To present the 'Wise List' (a formulary of essential medicines for primary and specialised care in Stockholm Healthcare Region) and assess adherence to the recommendations over a 15-year period.


Retrospective analysis of all prescription data in the Stockholm Healthcare Region between 2000 and 2015 in relation to the Wise List recommendations during the same time period.


All outpatient care in the Stockholm Healthcare Region.


All prescribers in the Stockholm Healthcare Region.


The number of core and complementary substances included in the Wise List, the adherence to recommendations by Anatomic Therapeutic Chemical (ATC) 1st level using defined daily doses (DDDs) adjusted to the DDD for 2015, adherence to recommendations over time measured by dispensed prescriptions yearly between 2002 and 2015.


The number of recommended core substances was stable (175-212). Overall adherence to the recommendations for core medicines for all prescribers increased from 75% to 84% (2000 to 2015). The adherence to recommendations in primary care for core medicines increased from 80% to 90% (2005 to 2015) with decreasing range in practice variation (32% to 13%). Hospital prescriber adherence to core medicine recommendations was stable but increased for the combination core and complementary medicines from 77% to 88% (2007 to 2015). Adherence varied between the 4 therapeutic areas studied.


High and increasing adherence to the Wise List recommendations was seen for all prescriber categories. The transparent process for developing recommendations involving respected experts and clinicians using strict criteria for handling potential conflicts of interests, feedback to prescribers, continuous medical education and financial incentives are possible contributing factors. High-quality evidence-based recommendations to prescribers, such as the Wise List, disseminated through a multifaceted approach, will become increasingly important and should be developed further to include recommendations and introduction protocols for new expensive medicines.


Adherence; Drug and therapeutics committee; Essential medicines; Health systems; Rational Use of Medicines; prescribing

[Indexed for MEDLINE]
Free PMC Article

Conflict of interest statement

Competing interests: JE is the member of an expert panel of the Stockholm DTC since 2013. KA, PB-R, MJ-H, MJ, M-LO and BW are employed by Stockholm Healthcare Region that finances the Drug and Therapeutics Committee (DTC) issuing the ‘Wise List’ in Stockholm. EA-K served as the chair-woman of Stockholm DTC 2010–2016, LLG as the chairman 2000–2009 and GL is the chair-woman since 2016 and REM deputy chairman since 2016.

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center