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J Cyst Fibros. 2019 May;18(3):364-367. doi: 10.1016/j.jcf.2019.01.001. Epub 2019 Jan 9.

High airborne level of Aspergillus fumigatus and presence of azole-resistant TR34/L98H isolates in the home of a cystic fibrosis patient harbouring chronic colonisation with azole-resistant H285Y A. fumigatus.

Author information

1
CHU Lille, Laboratoire de Parasitologie-Mycologie, F-59000 Lille, France; Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR8204 - CIIL - Center for Infection and Immunity of Lille, F-59000 Lille, France.
2
Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR8204 - CIIL - Center for Infection and Immunity of Lille, F-59000 Lille, France; CHU Lille, Unité de pneumologie et allergologie pédiatriques, Centre de Ressources et de Compétences de la Mucoviscidose (CRCM), F-59000 Lille, France.
3
APPA Hauts-de-France, F-59000 Lille, France.
4
CHU Lille, Clinique des Maladies Respiratoires, Centre de Ressources et de Compétences de la Mucoviscidose (CRCM), F-59000 Lille, France.
5
CHU Lille, Laboratoire de Parasitologie-Mycologie, F-59000 Lille, France; Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR8204 - CIIL - Center for Infection and Immunity of Lille, F-59000 Lille, France. Electronic address: emilie.frealle@chru-lille.fr.

Abstract

Azole-resistant Aspergillus fumigatus (ARAF) has been reported in the domestic environment of patients at risk for aspergillosis. Here, we assessed the mother's and father's homes of an 18-year-old cystic fibrosis patient harbouring chronic colonisation with H285Y CYP51A azole-resistant isolate, in order to explore the link between environmental exposure and ARAF infection. In one dwelling, a very high overall contamination level was found (710-7.240 CFU/m3), with a predominance of A. fumigatus (640-6.490 CFU/m3), and ARAF showing the TR34/L98H mutation was isolated. Mycological follow-up of the patient showed the persistence of H285Y isolates, but no acquisition of TR34/L98H isolates was observed. This could be due to the low proportion of TR34/L98H isolates (<3%), or the establishment of preventative measures and dwelling remediation taken after the environmental investigation. Our data underlines the value of an environmental assessment to establish preventative measures and limit the risk of A. fumigatus exposure and ARAF acquisition.

KEYWORDS:

Aspergillus fumigatus; Azole-resistance; Cystic fibrosis; Indoor mould exposure

PMID:
30638825
DOI:
10.1016/j.jcf.2019.01.001

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