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Appl Environ Microbiol. 2010 Apr;76(8):2681-3. doi: 10.1128/AEM.02841-09. Epub 2010 Mar 5.

Heterologous expression of the oxytetracycline biosynthetic pathway in Myxococcus xanthus.

Author information

1
Department of Chemistry, Syracuse University, Syracuse, New York 132441, USA.

Abstract

New natural products for drug discovery may be accessed by heterologous expression of bacterial biosynthetic pathways in metagenomic DNA libraries. However, a "universal" host is needed for this experiment. Herein, we show that Myxococcus xanthus is a potential "universal" host for heterologous expression of polyketide biosynthetic gene clusters.

PMID:
20208031
PMCID:
PMC2849223
DOI:
10.1128/AEM.02841-09
[Indexed for MEDLINE]
Free PMC Article

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