Format

Send to

Choose Destination

See 1 citation found by title matching your search:

Science. 2018 Aug 3;361(6401). pii: eaan5835. doi: 10.1126/science.aan5835.

Here, there, and everywhere: The importance of ER membrane contact sites.

Author information

1
Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309, USA.
2
Sir William Dunn School of Pathology, University of Oxford, Oxford, England, UK. pedro.carvalho@path.ox.ac.uk gia.voeltz@colorado.edu.
3
Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309, USA. pedro.carvalho@path.ox.ac.uk gia.voeltz@colorado.edu.

Abstract

Our textbook image of organelles has changed. Instead of revealing isolated cellular compartments, the picture now emerging shows organelles as largely interdependent structures that can communicate through membrane contact sites (MCSs). MCSs are sites where opposing organelles are tethered but do not fuse. MCSs provide a hybrid location where the tool kits of two different organelles can work together to perform vital cellular functions, such as lipid and ion transfer, signaling, and organelle division. Here, we focus on MCSs involving the endoplasmic reticulum (ER), an organelle forming an extensive network of cisternae and tubules. We highlight how the dynamic ER network regulates a plethora of cellular processes through MCSs with various organelles and with the plasma membrane.

PMID:
30072511
PMCID:
PMC6568312
DOI:
10.1126/science.aan5835
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center