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Biosci Biotechnol Biochem. 2011;75(4):774-6. Epub 2011 Apr 22.

Hepatic oxidoreduction-related genes are upregulated by administration of hydrogen-saturated drinking water.

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Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan.


The effects of the administration of molecular hydrogen-saturated drinking water (hydrogen water) on hepatic gene expression were investigated in rats. Using DNA microarrays, 548 upregulated and 695 downregulated genes were detected in the liver after 4 weeks of administration of hydrogen water. Gene Ontology analysis revealed that genes for oxidoreduction-related proteins, including hydroxymethylglutaryl CoA reductase, were significantly enriched in the upregulated genes.

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