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Sci Rep. 2014 Dec 11;4:7431. doi: 10.1038/srep07431.

Helicobacter pylori genetic diversity and gastro-duodenal diseases in Malaysia.

Author information

1
Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur Malaysia.
2
Malaysian Genomics Resource Centre Berhad, 59200 Kuala Lumpur Malaysia.
3
School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney NSW 2052 Australia.
4
Department of Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur Malaysia.

Abstract

Helicobacter pylori infection results in diverse clinical conditions ranging from chronic gastritis and ulceration to gastric adenocarcinoma. Among the multiethnic population of Malaysia, Indians consistently have a higher H. pylori prevalence as compared with Chinese and Malays. Despite the high prevalence of H. pylori, Indians have a relatively low incidence of peptic ulcer disease and gastric cancer. In contrast, gastric cancer and peptic ulcer disease incidence is high in Chinese. H. pylori strains from Chinese strains predominantly belong to the hspEAsia subpopulation while Indian/Malay strains mainly belong to the hspIndia subpopulation. By comparing the genome of 27 Asian strains from different subpopulations, we identified six genes associated with risk of H. pylori-induced peptic ulcer disease and gastric cancer. This study serves as an important foundation for future studies aiming to understand the role of bacterial factors in H. pylori-induced gastro-duodenal diseases.

PMID:
25503415
PMCID:
PMC5377019
DOI:
10.1038/srep07431
[Indexed for MEDLINE]
Free PMC Article

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