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Items: 1 to 20 of 103


Superoxide dismutases: Dual roles in controlling ROS damage and regulating ROS signaling.

Wang Y, Branicky R, Noë A, Hekimi S.

J Cell Biol. 2018 Jun 4;217(6):1915-1928. doi: 10.1083/jcb.201708007. Epub 2018 Apr 18. Review.


Estimating the occurrence of primary ubiquinone deficiency by analysis of large-scale sequencing data.

Hughes BG, Harrison PM, Hekimi S.

Sci Rep. 2017 Dec 18;7(1):17744. doi: 10.1038/s41598-017-17564-y.


Many possible maximum lifespan trajectories.

Hughes BG, Hekimi S.

Nature. 2017 Jun 28;546(7660):E8-E9. doi: 10.1038/nature22786. No abstract available.


Proteostasis or Aging: Let the CHIPs Fall Where They May.

Branicky R, Hekimi S.

Dev Cell. 2017 Apr 24;41(2):126-128. doi: 10.1016/j.devcel.2017.04.006. Review.


Pathogenicity of two COQ7 mutations and responses to 2,4-dihydroxybenzoate bypass treatment.

Wang Y, Smith C, Parboosingh JS, Khan A, Innes M, Hekimi S.

J Cell Mol Med. 2017 Oct;21(10):2329-2343. doi: 10.1111/jcmm.13154. Epub 2017 Apr 13.


A single biochemical activity underlies the pleiotropy of the aging-related protein CLK-1.

Liu JL, Yee C, Wang Y, Hekimi S.

Sci Rep. 2017 Apr 12;7(1):859. doi: 10.1038/s41598-017-00754-z.


Making a splash with splicing.

Branicky R, Hekimi S.

Cell Res. 2017 Apr;27(4):457-458. doi: 10.1038/cr.2017.24. Epub 2017 Feb 24.


Functional Requirements for Heparan Sulfate Biosynthesis in Morphogenesis and Nervous System Development in C. elegans.

Blanchette CR, Thackeray A, Perrat PN, Hekimi S, Bénard CY.

PLoS Genet. 2017 Jan 9;13(1):e1006525. doi: 10.1371/journal.pgen.1006525. eCollection 2017 Jan.


Mitochondrial ROS and the Effectors of the Intrinsic Apoptotic Pathway in Aging Cells: The Discerning Killers!

Hekimi S, Wang Y, Noë A.

Front Genet. 2016 Sep 14;7:161. doi: 10.3389/fgene.2016.00161. eCollection 2016. Review.


Antioxidants reveal an inverted U-shaped dose-response relationship between reactive oxygen species levels and the rate of aging in Caenorhabditis elegans.

Desjardins D, Cacho-Valadez B, Liu JL, Wang Y, Yee C, Bernard K, Khaki A, Breton L, Hekimi S.

Aging Cell. 2017 Feb;16(1):104-112. doi: 10.1111/acel.12528. Epub 2016 Sep 28.


Different Mechanisms of Longevity in Long-Lived Mouse and Caenorhabditis elegans Mutants Revealed by Statistical Analysis of Mortality Rates.

Hughes BG, Hekimi S.

Genetics. 2016 Nov;204(3):905-920. doi: 10.1534/genetics.116.192369. Epub 2016 Sep 16.


Understanding Ubiquinone.

Wang Y, Hekimi S.

Trends Cell Biol. 2016 May;26(5):367-378. doi: 10.1016/j.tcb.2015.12.007. Epub 2016 Jan 27. Review.


Mitochondrial dysfunction and longevity in animals: Untangling the knot.

Wang Y, Hekimi S.

Science. 2015 Dec 4;350(6265):1204-7. doi: 10.1126/science.aac4357. Review.


Coenzyme Q10 restores oocyte mitochondrial function and fertility during reproductive aging.

Ben-Meir A, Burstein E, Borrego-Alvarez A, Chong J, Wong E, Yavorska T, Naranian T, Chi M, Wang Y, Bentov Y, Alexis J, Meriano J, Sung HK, Gasser DL, Moley KH, Hekimi S, Casper RF, Jurisicova A.

Aging Cell. 2015 Oct;14(5):887-95. doi: 10.1111/acel.12368. Epub 2015 Jun 26.


Mitochondrial function and lifespan of mice with controlled ubiquinone biosynthesis.

Wang Y, Oxer D, Hekimi S.

Nat Commun. 2015 Mar 6;6:6393. doi: 10.1038/ncomms7393.


A microfluidic device for efficient chemical testing using Caenorhabditis elegans.

Song P, Zhang W, Sobolevski A, Bernard K, Hekimi S, Liu X.

Biomed Microdevices. 2015 Apr;17(2):38. doi: 10.1007/s10544-015-9939-8.


Mitochondrial and cytoplasmic ROS have opposing effects on lifespan.

Schaar CE, Dues DJ, Spielbauer KK, Machiela E, Cooper JF, Senchuk M, Hekimi S, Van Raamsdonk JM.

PLoS Genet. 2015 Feb 11;11(2):e1004972. doi: 10.1371/journal.pgen.1004972. eCollection 2015 Feb.


Compensatory elevation of voluntary activity in mouse mutants with impaired mitochondrial energy metabolism.

Lapointe J, Hughes BG, Bigras E, Hekimi S.

Physiol Rep. 2014 Nov 20;2(11). pii: e12214. doi: 10.14814/phy2.12214. Print 2014 Nov 1.


The intrinsic apoptosis pathway mediates the pro-longevity response to mitochondrial ROS in C. elegans.

Yee C, Yang W, Hekimi S.

Cell. 2014 May 8;157(4):897-909. doi: 10.1016/j.cell.2014.02.055.


CEP-1, the Caenorhabditis elegans p53 homolog, mediates opposing longevity outcomes in mitochondrial electron transport chain mutants.

Baruah A, Chang H, Hall M, Yuan J, Gordon S, Johnson E, Shtessel LL, Yee C, Hekimi S, Derry WB, Lee SS.

PLoS Genet. 2014 Feb 27;10(2):e1004097. doi: 10.1371/journal.pgen.1004097. eCollection 2014 Feb.

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