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Am J Vet Res. 2001 Jun;62(6):823-7.

Myofibroblasts in the accessory ligament (distal check ligament) and the deep digital flexor tendon of foals.

Author information

1
Laboratory for Comparative Orthopaedic Research, College of Veterinary Medicine, Michigan State University, East Lansing 48824, USA.

Abstract

OBJECTIVE:

To demonstrate myofibroblasts in the accessory ligament of the deep digital flexor tendon (ie, distal check ligament) and deep digital flexor tendon of clinically normal foals.

SAMPLE POPULATION:

Tissue specimens from 25 foals that were necropsied for reasons unrelated to this study and unrelated to musculoskeletal disease.

PROCEDURE:

The distal check ligament and deep digital flexor tendon of both forelimbs were examined histologically. Myofibroblasts were identified by immunohistochemical staining specific for alpha-smooth muscle actin (alpha-SMA).

RESULTS:

Most of the cells in the distal check ligament and deep digital flexor tendon of all foals stained positive for alpha-SMA.

CONCLUSION AND CLINICAL RELEVANCE:

Myofibroblasts made up most of the cells in the distal check ligament and deep digital flexor tendon of clinically normal foals. These cells have contractile ability and therefore, may play a role in flexure contracture of these tendons. The ability of tetracycline to chelate calcium or decrease the expression of the contractile protein alpha-smooth muscle actin could inhibit the myofibroblasts' ability to contract, thus providing a rationale for tetracycline administration as a treatment of distal interphalangeal joint flexor deformity in foals.

PMID:
11400835
[Indexed for MEDLINE]

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