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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1991 1
1995 2
1999 2
2003 2
2004 4
2005 2
2007 2
2008 1
2009 1
2010 3
2011 2
2012 2
2013 2
2014 4
2015 3
2016 2
2017 1
2023 1
2024 0

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34 results

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Page 1
Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors.
Yin J, Babaoglu K, Brautigam CA, Clark L, Shao Z, Scheuermann TH, Harrell CM, Gotter AL, Roecker AJ, Winrow CJ, Renger JJ, Coleman PJ, Rosenbaum DM. Yin J, et al. Among authors: harrell cm. Nat Struct Mol Biol. 2016 Apr;23(4):293-9. doi: 10.1038/nsmb.3183. Epub 2016 Mar 7. Nat Struct Mol Biol. 2016. PMID: 26950369
Investigation of orexin-2 selective receptor antagonists: Structural modifications resulting in dual orexin receptor antagonists.
Skudlarek JW, DiMarco CN, Babaoglu K, Roecker AJ, Bruno JG, Pausch MA, O'Brien JA, Cabalu TD, Stevens J, Brunner J, Tannenbaum PL, Wuelfing WP, Garson SL, Fox SV, Savitz AT, Harrell CM, Gotter AL, Winrow CJ, Renger JJ, Kuduk SD, Coleman PJ. Skudlarek JW, et al. Among authors: harrell cm. Bioorg Med Chem Lett. 2017 Mar 15;27(6):1364-1370. doi: 10.1016/j.bmcl.2017.02.012. Epub 2017 Feb 9. Bioorg Med Chem Lett. 2017. PMID: 28216403
Identification of MK-8133: An orexin-2 selective receptor antagonist with favorable development properties.
Kuduk SD, Skudlarek JW, DiMarco CN, Bruno JG, Pausch MH, O'Brien JA, Cabalu TD, Stevens J, Brunner J, Tannenbaum PL, Garson SL, Savitz AT, Harrell CM, Gotter AL, Winrow CJ, Renger JJ, Coleman PJ. Kuduk SD, et al. Among authors: harrell cm. Bioorg Med Chem Lett. 2015 Jun 15;25(12):2488-92. doi: 10.1016/j.bmcl.2015.04.066. Epub 2015 Apr 29. Bioorg Med Chem Lett. 2015. PMID: 25981685
Promotion of sleep by suvorexant-a novel dual orexin receptor antagonist.
Winrow CJ, Gotter AL, Cox CD, Doran SM, Tannenbaum PL, Breslin MJ, Garson SL, Fox SV, Harrell CM, Stevens J, Reiss DR, Cui D, Coleman PJ, Renger JJ. Winrow CJ, et al. Among authors: harrell cm. J Neurogenet. 2011 Mar;25(1-2):52-61. doi: 10.3109/01677063.2011.566953. Epub 2011 Apr 8. J Neurogenet. 2011. PMID: 21473737
Benzodiazepines as potent and selective bradykinin B1 antagonists.
Wood MR, Kim JJ, Han W, Dorsey BD, Homnick CF, DiPardo RM, Kuduk SD, MacNeil T, Murphy KL, Lis EV, Ransom RW, Stump GL, Lynch JJ, O'Malley SS, Miller PJ, Chen TB, Harrell CM, Chang RS, Sandhu P, Ellis JD, Bondiskey PJ, Pettibone DJ, Freidinger RM, Bock MG. Wood MR, et al. Among authors: harrell cm. J Med Chem. 2003 May 8;46(10):1803-6. doi: 10.1021/jm034020y. J Med Chem. 2003. PMID: 12723943
Potent bradykinin B1 receptor antagonists: 4-substituted phenyl cyclohexanes.
Su DS, Lim JL, Markowitz MK, Wan BL, Murphy KL, Reiss DR, Harrell CM, O'Malley SS, Ransom RW, Chang RS, Pettibone DJ, Tang C, Prueksaritanont T, Freidinger RM, Bock MG. Su DS, et al. Among authors: harrell cm. Bioorg Med Chem Lett. 2007 Jun 1;17(11):3006-9. doi: 10.1016/j.bmcl.2007.03.059. Epub 2007 Mar 21. Bioorg Med Chem Lett. 2007. PMID: 17428657
2,3-diaminopyridine bradykinin B1 receptor antagonists.
Kuduk SD, Ng C, Feng DM, Wai JM, Chang RS, Harrell CM, Murphy KL, Ransom RW, Reiss D, Ivarsson M, Mason G, Boyce S, Tang C, Prueksaritanont T, Freidinger RM, Pettibone DJ, Bock MG. Kuduk SD, et al. Among authors: harrell cm. J Med Chem. 2004 Dec 16;47(26):6439-42. doi: 10.1021/jm049394l. J Med Chem. 2004. PMID: 15588075
Orexin 2 Receptor Antagonism is Sufficient to Promote NREM and REM Sleep from Mouse to Man.
Gotter AL, Forman MS, Harrell CM, Stevens J, Svetnik V, Yee KL, Li X, Roecker AJ, Fox SV, Tannenbaum PL, Garson SL, Lepeleire ID, Calder N, Rosen L, Struyk A, Coleman PJ, Herring WJ, Renger JJ, Winrow CJ. Gotter AL, et al. Among authors: harrell cm. Sci Rep. 2016 Jun 3;6:27147. doi: 10.1038/srep27147. Sci Rep. 2016. PMID: 27256922 Free PMC article. Clinical Trial.
34 results